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Anticholinergics and Amantadine

Important! You should always read carefully the information leaflet that comes with your medication before you start using it. Always check with your doctor or other healthcare professional before altering any of your medications or taking over-the-counter medications as they can interfere with Parkinson’s medications and may have unwanted side effects. Remember also to tell your doctor if you take over-the-counter drugs that can be bought without a prescription.


What you should know about your Parkinson's medication

Each medication has its own particular properties and important considerations to be aware of. Below are some key aspects to think about before you start taking your medication. Detailed information regarding these can be found in the Patient Information Leaflet (PIL):

  • what is it and what is it used for?
  • special warnings and precautions
  • how to take it
  • possible side effects
  • contraindications (when not to use it)
  • interaction with other medication(s)
  • what to do if you forget to take a dose
  • what to do if you take more than you should
  • possible effects on your ability to drive or use machinery
  • safety in pregnancy and breast-feeding
  • how to store.
Parkinson's medication overview
Generic name Brand name ®

Anticholinergics

  • Benztropine
  • Orphenadrine
  • Procyclidine
  • Trihexyphenidyl (formerly benzhexol)
  • Cogentin
  • Disipal
  • Apricolin
    Kemadrin
  • Broflex

Amantadine

  • Amantadine
  • Symmetrel

The active ingredient in Disipal® Tablets belongs to the group of medicines called anticholinergic agents. Disipal® Tablets are used in the treatment of all forms of Parkinson’s, a condition which can cause uncontrollable trembling of the hands, and other difficulties of movement, for example in standing or walking. Anticholinergic agents are also used when other medicines have caused these problems.

Procyclidine belongs to a group of medicines called anticholinergics. Anticholinergics stop a substance called acetylcholine working in your body.

Procyclidine is predominantly used in Parkinson’s to help with muscle control and reducing stiffness.

Patient Information Leaflet (PIL)

The PIL is the leaflet that is included with a medicine and is a patient-friendly version of the Summary of Product Characteristics. It gives information about taking or using a medicine.

The following links provide detailed, up-to-date information on Kemadril®, its handling and use. As information leaflets are approved by the regulatory body in each country in which a medication is licensed – and are therefore too numerous to list – we have included only the UK examples. These links go to the Electronic Medicines Compendium (eMC) website.

Summary of Product Characteristics (SPC)

The SPC is used by healthcare professionals and explains how to use and prescribe a medicine.

Trihexyphenidyl belongs to a group of medicines called anticholinergics. Anticholinergics stop a substance called acetylcholine working in your body.

Trihexyphenidyl is a muscle-relaxant. It is used to treat Parkinson’s symptoms such as tremor or muscle stiffness which can make movement difficult.

Patient Information Leaflet (PIL)

The PIL is the leaflet that is included with a medicine and is a patient-friendly version of the Summary of Product Characteristics. It gives information about taking or using a medicine.

The following links provide detailed, up-to-date information on Trihexyphenidyl, its handling and use. As information leaflets are approved by the regulatory body in each country in which a medication is licensed – and are therefore too numerous to list – we have included only the UK examples. These links go to the Electronic Medicines Compendium (eMC) website.

  • Trihexyphenidyl 2 mg & 5 mg Tablets - Download PIL 
  • Trihexyphenidyl Hydrochloride 5 mg / 5 ml Syrup - Download PIL

Summary of Product Characteristics (SPC)

The SPC is used by healthcare professionals and explains how to use and prescribe a medicine.

  • Trihexyphenidyl 2 mg & 5 mg Tablets - Download SPC 
  • Trihexyphenidyl Hydrochloride 5 mg / 5 ml Syrup - Download SPC

Symmetrel® is a dopaminergic drug which means it can increase the levels of certain chemicals which transmit impulses in the nervous system, including the brain. It is used to treat Parkinson’s by improving muscle control and reducing stiffness, shakiness and shuffling. 

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