Possible Undesirable Effects of Madopar ®
These are the most commonly reported undesirable effects with Madopar® in clinical studies, however it does not necessarily mean that you will experience some or all of them.
For full information about possible undesirable effects you should read the package information or talk to your doctor.
At the beginning of treatment, loss of appetite, nausea, vomiting and diarrhoea can occur. These symptoms can usually be bought under control by taking the medicine during, or immediately after meals or with sufficient food or liquid and by increasing the dose slowly.
Occasional intestinal bleeding.
Occasional reports of cardiac arrhythmias and orthostatic hypotension.
Rarely allergic reactions such as pruritus and rash.
Psychiatric problems are common in Parkinsonian patients, including those being treated with levodopa. They include feeling in high spirits, anxiety, agitation, insomnia, drowsiness, depression, aggression, delusions, hallucinations, temporal disorientation. Sleep disturbances, feelings of unrest, anxiety, depressed mood, somnolence (excessive drowsiness), sudden sleep onset, and other psychiatric reactions may occur.
Involuntary movements are common, particularly on long-term administration. These are usually dose-dependent and may disappear or become tolerable after dose adjustment.
Occasionally hot flushes, sweating and drowsiness have been reported by patients taking levodopa.
Sometimes your urine may be coloured red and turn dark if left to stand. The changes are the result of the action of the drug and are no cause for concern.
Tolerance to Madopar varies widely between patients and is often related to the rate of dosage increases. With long-term administration fluctuations in the therapeutic response may be encountered. They include “freezing” episodes, end-of-dose deterioration and the so-called “on-off” effect. Patients may be helped by dosage reduction or by giving smaller and more frequent doses.