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The Q10 questionnaire for detection of wearing-off phenomena in Parkinson's disease

The Q10 questionnaire for detection of wearing-off phenomena in Parkinson's disease
Predictive factors affecting early deterioration of axial symptoms after subthalamic nucleus stimulation in Parkinson's disease
Parkinsonism and Related Disorders

May 20112
Martinez-Martin P, Hernandez B; on behalf of the Q10 Study Group


In Parkinson’s disease (PD), wearing-off can be difficult to detect as it is very variable and may affect motor and non-motor symptoms.

The Wearing-Off Questionnaire, WOQ-32 (Stacy et al., 2005), was introduced to help identify wearing-off and proved to be very efficient. Two short versions of the questionnaire (WOQ-19 or QUICK and WOQ-9) were later developed to decrease the respondent burden without loss of efficacy in terms of sensitivity.

The objective of the present study was to check the ability of a new 10-item QUICK version, Q10, to identify patients with wearing-off. Q10 items were selected from the QUICK validation study data set through statistical analysis and it was then tested on a sample of 162 PD patients, 64.8% with wearing-off. Sensitivity, specificity, and accuracy were 96%, 63%, and 85% respectively with one positive response and 90%, 70%, and 83% respectively with two positive responses.

The correlation with the gold standard (neurologist diagnosis of wearing-off) was substantial (kappa = 0.62–0.64). Comparison with the QUICK and WOQ-9 shows that the Q10 can be a new tool for detection of wearing-off with satisfactory properties and a good balance between brevity and performance.