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Cognition and Parkinson's Disease: the Patient's Perspective
While changes in cognition are common in people with Parkinson's disease, there is limited understanding about how individuals perceive cognitive difficulties and how it impacts everyday activities. This report provides not only more understanding about this complex symptom, but also more information for patients, family and friends, caregivers, and clinicians.
20 October 2016
Neuropsychological outcomes from constant current deep brain stimulation for Parkinson's disease
Conclusions: Constant-current bilateral subthalamic stimulation had a good cognitive safety profile except for decrements in verbal fluency and on the Stroop task. These abnormalities are related to device implantation, but stimulation likely had an additive effect. One year after surgery, the cognitive changes did not exert a detrimental effect on quality of life, although letter fluency declines were associated with communication dissatisfaction at 12 months.
18 October 2016
Frenchay dysarthria assessment (FDA-2) in Parkinson's: cross-cultural adaptation & psychometric properties of European ....
The EP-FDA-2 has shown the salient features of a valid tool that can be used by speech and language therapists in the assessment of dysarthria in PD in clinical practice as in the research field.
17 October 2016
Reduced MIBG accumulation of the parotid and submandibular glands in idiopathic Parkinson's disease
Conclusion: MIBG uptake in the parotid and submandibular glands might be a candidate biomarker for PD. The missing correlation between MIBG uptake and clinical PD parameters suggests that ASP of the extracranial sympathetic superior cervical ganglion, which innervates the major salivary glands, develops independently from the cerebral dopaminergic nigrostriatal ASP.
15 October 2016
Subthalamic stimulation and levodopa modulate cortical reactivity in Parkinson's patients
Study data reveal that bilateral STN-DBS and LD therapy induce a modulation of specific cortical components and specific ranges of frequency. These findings demonstrate that STN-DBS and LD therapy may have synergistic effects on motor cortical activity.
14 October 2016
Chemical Compensation of Mitochondrial Phospholipid Depletion in Yeast and Animal Models of Parkinson's Disease
Exposure to cyclosporine, meclofenoxate, and sulfaphenazole significantly enhanced survival at day 7 in α-syn-expressing worm populations whereby 5055% of the populations displayed normal neurons, compared to only 1015% of untreated animals. Authors also found that all three drugs rescued worms expressing α-syn in dopaminergic neurons that were deficient in the phospholipid cardiolipin following cardiolipin synthase (crls-1) depletion by RNAi.
13 October 2016
A randomized trial of inhaled levodopa (CVT-301) for motor fluctuations in Parkinson's disease
Results: Eighty-six patients used the study drug at an average frequency of 2.1 times per day for CVT-301 and for placebo. At 4 weeks, least-squares mean change in UPDRS Part III score favored CVT-301 by 7.0 points (P < 0.001). A treatment effect was evident at 10 minutes. At 4 weeks, least-squares mean OFF-time change from baseline favored CVT-301 by 0.9 hours per day (P = 0.045). The most frequently reported adverse events in the CVT-301 group were dizziness, cough, and nausea, each in 7% (3 of 43 patient
15 September 2016
Caregiver report of apathy predicts dementia in Parkinson's disease
Conclusions: A simple, caregiver-reported measure of apathy is an independent predictor of progression to dementia in PD. This highlights the importance of apathy as a clinical characteristic of PD and could prove useful for the prediction of future dementia.
01 August 2015
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