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  • Movement Disorders Volume 29 Issue 7 Microstructural changes in white matter associated with freezing of gait in Parkinson's diseaseAuthors conclude that FOG is associated with diffuse white matter damage involving major cortico-cortical, corticofugal motor, and several striatofrontal tracts in addition to previously described cerebello-pontine connectivity changes. These distributed white matter abnormalities may contribute to the motor and non-motor correlates of FOG. 16 January 2015
  • Movement Disorders Volume 29 Issue 7 Freezing of gait in Parkinson's disease is related to impaired motor switching during steppingThese findings suggest that motor set switching deficits, commonly reported in tasks using verbal or tapping responses, extend to stepping and can contribute to the occurrence of freezing episodes during gait initiation. 16 January 2015
  • Movement Disorders Volume 29 Issue 7 Entacapone and Prostate Cancer Risk in Patients With Parkinson's DiseaseUse of entacapone with l-dopa/dopa decarboxylase inhibitor caused no increased risk of prostate cancer incidence (hazard ratio [HR]: 1.05; 95% confidence interval: 0.76-1.44) or mortality (0.93; 0.43-1.98). The HR for cumulative entacapone use of >360 days versus never-use was 0.82 (0.56-1.18) for prostate cancer incidence and 1.27 (0.60-2.72) for prostate cancer mortality. 16 January 2015
  • xxx Improving l-dopa therapy: The development of enzyme inhibitorsThe introduction of levodopa produced a monumental change in the treatment of Parkinson's disease (PD). Limitations in its bioavailability and tolerability led to the search for drugs that could improve its pharmacokinetics and safety profile. 15 January 2015
  • xxx Central pharmacokinetics of levodopa: Lessons from imaging studiesTaken together, the studies provide in vivo validation for the hypothesis that pulsatile stimulation of dopamine receptors plays a critical role in the emergence of long-term motor complications of therapy. Similar approaches can be used to study the non-motor complications of PD and its treatment. 15 January 2015
  • Movement Disorders Volume 29 Issue 7 Statins, plasma cholesterol, and risk of Parkinson's disease: A prospective studyStatin use may be associated with a higher PD risk, whereas higher total cholesterol may be associated with lower risk. These data are inconsistent with the hypothesis that statins are protective against PD. 14 January 2015
  • Movement Disorders Volume 29 Issue 7 [11C]-(+)-PHNO PET imaging of dopamine D2/3 receptors in Parkinson's disease with impulse control disordersAuthors conclude that although D3 dopamine receptors have been linked to the occurrence of ICD in Parkinson's patients. Findings do not support the hypothesis that D3 receptor levels are elevated in Parkinson's patients with ICD. We also did not find ICD-related abnormalities in D2 receptor levels. Our findings argue against the possibility that differences in D2/3 receptor levels can account for the development of ICD in PD; however, authors cannot rule out that differences in dopamine levels (particularly 14 January 2015
  • xxx Dopamine agonists early monotherapy for the delay of development of levodopa-induced dyskinesiasThis article highlights some interesting aspects of the clinical trials testing dopamine agonists monotherapy as a strategy that can reduce the risk of motor complications, and raises some concerns in terms of their early use in Parkinson's disease treatment to prevent or delay dyskinesia. 12 January 2015
  • xxx Levodopa: Effect on cell death and the natural history of Parkinson's diseaseThis review article considers the question of whether or not levodopa is toxic in Parkinson's disease (PD). l-dopa is the most effective symptomatic treatment for PD and has provided benefit for millions of patients. However, there has been a longstanding concern that l-dopa might be toxic and accelerate neuronal degeneration and clinical progression as a consequence of reactive oxygen species generated by the drug's oxidative metabolism. 11 January 2015
  • xxx Decreased interhemispheric functional connectivity in subtypes of Parkinson's diseaseThese findings suggest that functional coordination between homotopic brain regions is impaired in AR-PD and TD-PD patients. This study provides evidence of both cerebellum-related connectivity deficits in TD-PD. The finding that VMHC values and tremor scores were significantly correlated suggests that VMHC measurements may be of potential clinical relevance in TD-PD. 11 January 2015
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