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Past smoking & current dopamine agonist use show independent & dose-dependent association with impulse control disorders in PDConclusions: Dopaminergic stimulation and previous exposure to smoking are independently associated with impulse control disorders in a dose-dependent manner. 01 July 2013
Parkinson's disease is associated with altered expression of CaV1 channels and calcium-binding proteinsThe finding of increased CaV1.3 subtype expression in the cerebral cortex of early stage Parkinson's disease, before the appearance of pathological changes, supports the view that disturbed calcium homeostasis is an early feature of Parkinson's disease and not just a compensatory consequence to the neurodegenerative process. 14 June 2013
Autonomic dysfunction in parkinsonian LRRK2 mutation carriersCarriers of the LRRK2 mutation had less autonomic impairment than those with iPD as shown by higher cardiac MIBG uptake and a tendency to less impairment of autonomic non-invasive tests. It is important to carry out larger studies comparing the clinical, functional and pathological characteristics of these patients. 12 June 2013
Technical aids & housing adaptations among very old people with self-reported Parkinson's compared to matched controlsResults: Very old people with self-reported Parkinson's disease use significantly more aids for personal mobility than very old people in general. They have, furthermore, a significant increased unmet need concerning aids for personal care and protection. Housing adaptations did not differ between the two groups. 11 June 2013
Nigral stimulation for resistant axial motor impairment in Parkinson's disease? A randomized controlled trialHere, authors hypothesized that the combined stimulation of subthalamic nucleus and substantia nigra pars reticulata improves axial symptoms compared with standard subthalamic nucleus stimulation. 11 June 2013
Association between dopaminergic medications and nocturnal sleep in early-stage Parkinson's diseaseConclusions: Higher amounts of dopaminergic medications taken prior to sleep were associated with poor sleep quality and less REM sleep. Although poor nocturnal sleep in PD is likely multi-factorial in etiology, study findings suggest that timing and dose of medications prior to sleep need to be considered in its management. 10 June 2013
Neuropathology of dementia in a large cohort of patients with Parkinson's diseaseThe aim of this study was to establish the contribution of distinct pathological aggregates (cortical Lewy bodies (LB), neuronal tau-inclusions and β-amyloid plaque (Aβ) deposition) in dementia related to Parkinson's disease (PD) in a large autopsy cohort. 10 June 2013
Lack of polysomnographic Non-REM sleep changes in early Parkinson's diseaseThe results confirmed a reduction in muscle atonia during REM sleep as a characteristic finding in early IPD. However, there were no further disease-inherent or medication-induced changes in sleep architecture. Although sleep disturbances are considered to be an integral part of IPD, PSG cannot yet identify them objectively at an early stage. 06 June 2013
MHCII Is Required for α-Synuclein-Induced Activation of Microglia, CD4 T Cell Proliferation, and Dopaminergic NeurodegenerationThese results indicate a central role for microglial MHCII in the activation of both the innate and adaptive immune responses to α-syn in PD and suggest that the MHCII signaling complex may be a target of neuroprotective therapies for the disease. 05 June 2013
Moving from physician-centered care towards patient-centered care for Parkinson's disease patientsHere, authors argue that an alternative way to organize health care, namely more from the patient's perspective, may help to contain costs, while improving the quality, safety and access to care. 05 June 2013

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