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  • Neuron Three Mechanisms by which Striatal Denervation Causes Breakdown of Dopamine SignalingThis analysis provides a quantitative, physiologically consistent view of the early and late stages of PD, the effect of main therapeutic medications, and potential side effects. The mechanisms described here may also provide an explanation to currently inexplicable pathological phenomena such as psycho stimulant-induced contraversive rotations in animal models. 10 September 2014
  • DNA Puerarin protects dopaminergic neurons in Parkinson's disease modelsThese data indicated that puerarin alleviated the oxidative stress and apoptosis in a PD cellular model, protected the dopaminergic neurons against rotenone toxicity and decreased the abnormal protein overexpressing in PD animal models. These findings suggest that puerarin may develop into a neuroprotective alternative for patients with PD. 10 September 2014
  • Neuron Dopamine transporter SLC6A3 genotype affects cortico-striatal activity of set-shifts in Parkinson's diseaseThis is the first study indicating that the SLC6A3/DAT1 genotype has a significant effect on fronto-striatal activation and performance in Parkinson's disease. This effect is stronger for conditions that engage the striatum. 10 September 2014
  • Man with stick The nature of tremor circuits in parkinsonian and essential tremorBased on these results we conclude that parkinsonian rest tremor is driven by a neural network, which includes the subthalamic nucleus and ventrolateral thalamus and has broad frequency-amplitude tolerance. We propose that it is this tolerance to changes in tremor frequency that dictates that parkinsonian rest tremor may be significantly entrained by low frequency stimulation without stimulation timing-dependent amplitude modulation. 08 September 2014
  • Quality of Life Friends Couple walking in woods Move for Change Part III: a European survey evaluating the impact of the EPDA Charter for People with Parkinson's DiseaseThese results highlight that PD disease-management is driven by the clinician; he/she arranges consultations and makes the majority of management decisions, rather than patients being included in the process. This survey can be used to raise awareness for PD patients, encouraging greater involvement in the management of PD 07 September 2014
  • Brain Later age at onset in Parkinson's disease over twenty years in an Italian tertiary clinicConclusions: Over the last two decades, age at onset of PD appeared to shift progressively towards more advanced age. However, sequential, high quality population-based incidence studies are required. to establish whether there is a trend towards increase in age at onset over and above general population ageing and to assess whether the increase is associated with the improvement in medical and socio-economic conditions. 05 September 2014
  • Brain Topographic pattern of cortical thinning with consideration of motor laterality in parkinson diseaseThe study's Our right-handed PD population revealed that significant thinning of motor-related cortical areas in contralateral hemisphere to symptomatic side in LPD, but not in RPD group. Results support that neuroprotective effect of enhanced physical activity by handedness on contralateral motor cortex. 03 September 2014
  • Tablets Pooled analysis of phase III with entacapone in Parkinson's diseaseConclusions: Entacapone improved daily OFF- and ON-times by a mean of 0.8 h compared with placebo across the four pooled efficacy studies and was generally well tolerated. The results of this pooled analysis potentially serve as a useful benchmarking data for new therapies (especially levodopa products) in advanced patients with PD. 03 September 2014
  • Neuron Early-onset Parkinson's disease due to PINK1 p.Q456X mutation - Clinical and functional studyConclusions The PINK1 p.Q456X mutation leads to a decrease in mRNA and a loss of protein function. The foot dystonia and gait disorders seen at disease onset in affected members of our family, which were accompanied by parkinsonism had a similar clinical presentation to what has been described in previous reports of PINK1 mutation carriers. 03 September 2014
  • Test tubes Dietary fat intake and risk for Parkinson's diseaseThe study suggests that fat intake in general is not related to the risk for PD. The weak positive association between intake of n-6 PUFA and PD risk needs further investigation. 03 September 2014
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