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Rest tremor suppression may separate essential from Parkinsonian rest tremorAuthors conclude that the assessment of the suppression of rest tremor during movement initiation is a simple and reliable tool to separate PT from rest tremor in ET also suggesting that the mechanisms of rest tremor in these two diseases are different. 29 April 2013
Improving memory in Parkinson's disease: A healthy brain ageing cognitive training programAlthough the study was limited by the lack of randomized allocation to treatment and control groups, these findings suggest that a healthy brain ageing cognitive training program may be a viable tool to improve memory and/or slow cognitive decline in people with Parkinson's disease. It also appeared successful for increasing awareness of adaptive and/or compensatory cognitive strategies, as well as modifiable risk factors to optimize brain functioning. 29 April 2013
Factors predictive of the development of levodopa-induced dyskinesia and wearing-off in Parkinson's diseaseIn the current study, the STRIDE-PD study population was investigated to determine the effect of l-dopa dose and other risk factors on the development of dyskinesia and wearing-off. Patients were randomized to receive LCE (n=373) or LC (n=372). 29 April 2013
Effect of long-term treatment with pramipexole or levodopa on presynaptic markers assessed by longitudinal[123I]FP-CIT SPECT andIn conclusion, chronic dopaminergic stimulation with LD or PPX induced similar adaptive presynaptic changes in healthy mice, but no discernible changes in severely lesioned mice. These findings allow to more reliably interpret the results from clinical trials using neuroimaging of DAT as surrogate parameter. 28 April 2013
Behavioral characterization of the 6-hydroxidopamine model of Parkinson's and pharmacological rescuing of non-motor deficitsThese results suggest that this model is a relevant tool to study the pathophysiology of motor and non-motor symptoms of PD. In addition, the present data shows that pharmacological interventions modulating dopaminergic transmission are also relevant to revert the non-motor behavioral deficits found in the disease. 26 April 2013
PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged MitochondriaAuthors show that the mitochondrial outer membrane guanosine triphosphatase mitofusin (Mfn) 2 mediates Parkin recruitment to damaged mitochondria. Parkin bound to Mfn2 in a PINK1-dependent manner; PINK1 phosphorylated Mfn2 and promoted its Parkin-mediated ubiqitination. 26 April 2013
Cerebral white matter hyperintensity in Parkinson's disease: A major risk factor for mild cognitive impairmentThe influence of cerebral ischemia as a risk factor for MCI in PD has not been adequately investigated. To address this issue, authors examined the influence of the volume and distribution of white matter hyperintensity (WMH) as a risk factor for MCI in early PD. 26 April 2013
Permeabilization of the Blood-Brain Barrier via Mucosal Engrafting: Implications for Drug Delivery to the BrainHere authors describe a novel method of creating a semipermeable window in the BBB using purely autologous tissues to allow for high molecular weight(HMW) drug delivery to the CNS. 24 April 2013
Subthalamic Nucleus Neurons Are Synchronized to Primary Motor Cortex Local Field Potentials in Parkinson'sHere, in humans undergoing deep brain stimulator implantation surgery, authors use the novel technique of subdural electrocorticography in combination with subthalamic nucleus (STN) single-unit recording to study basal gangliacortex interactions at the millisecond time scale. 24 April 2013
Progress in gene therapy for neurological disordersIn this Review, authors describe the promising gene therapy strategies that have the potential to treat patients with neurological diseases and discuss prospects for future development of gene therapy. 23 April 2013

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