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Long-term safety and efficacy of preladenant in subjects with fluctuating Parkinson's diseaseConclusions: Long-term preladenant treatment (5 mg twice a day) was generally well tolerated and provided sustained OFF time reductions and ON time increases. 15 April 2013
Parkinson's disease patients show reduced cortical-subcortical sensorimotor connectivityThe purpose of this study was to measure anatomical and functional connectivity in groups of PD patients and controls to determine whether connectivity deficits within the corticobasal ganglia thalamocortical system could be attributed to PD, particularly in sensorimotor connections. 15 April 2013
Ocular Tremor in Parkinson's Disease Is Due to Head OscillationConclusions: The ocular tremor observed in patients with PD disease is a compensatory eye movement secondary to transmitted head tremor, in agreement with clinical wisdom that these patients do not report oscillopsia. 15 April 2013
Unimpaired postprandial pancreatic polypeptide secretion in Parkinson's disease and REM sleep behavior disorderResults: The postprandial pancreatic polypeptide secretion showed a physiological pattern in all groups and even an enhanced response in drug-naive PD and iRBD. Motilin concentrations correlated with pancreatic polypeptide concentrations. 15 April 2013
Association of pain, Parkinson's disease, and restless legs syndromeThe results showed that 21.3% of PD patients had RLS, compared to only 4.7% in the control group, representing a highly significant difference (p<0.005). The frequency of reporting pain was also significantly higher among PD patients with RLS (p<0.005), but not in control group. 15 April 2013
Designing a new scale to measure anxiety symptoms in Parkinson's disease: item selection based on canonical correlation analysisConclusions: BAI is heavily focused on panic symptoms, whilst HARS is more focused towards generalized anxiety symptoms. The new scale should include additional components in order to assess both episodic and persistent anxiety as well as items for evaluation of avoidance behaviour. 14 April 2013
A systematic review of biomarkers for disease progression in Parkinson's diseaseAuthors found insufficient evidence to recommend the use of any biomarker for disease progression in PD clinical trials, which may simply reflect the poor quality of research in this area. They therefore present a provisional 'roadmap' for conducting future disease progression biomarker studies, and recommend new quality criteria by which future studies may be judged. 12 April 2013
Lysosomal impairment in Parkinson's diseaseAccording to these new findings, primary lysosomal defects could potentially account for Lewy body formation and neurodegeneration in PD, laying the groundwork for the prospective development of new neuroprotective/disease-modifying therapeutic strategies aimed at restoring lysosomal levels and function. 11 April 2013
Cost-effectiveness of deep brain stimulation in patients with Parkinson's diseaseAuthors performed a cost-utility analysis using a lifetime Markov model for Parkinson's disease. Health utilities were evaluated using the EQ-5D generic health status measure. Data on effectiveness and adverse events were obtained from clinical studies, published reports, or meta-analyses. 10 April 2013
Determinants of delayed diagnosis in Parkinson's diseaseThe early and accurate diagnosis of Parkinson's disease (PD) is the first step towards optimal patient management. The aim of this study was to investigate the major determinants of delayed diagnosis in PD. 10 April 2013

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