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α-Synuclein and Neuronal Cell DeathIn this review, authors will focus on αSyn-triggered neuronal cell death and provide possible disease-modifying therapies targeting abnormally accumulating αSyn. 01 April 2013
Neuroinflammation and oxidative stress: Co-conspirators in the pathology of Parkinson's diseaseThis review will discuss neuroinflammation in PD, with particular focus on the genetic and toxin-based models of the disease. These studies have confirmed elevated oxidative stress and the pro-inflammatory response occurs early in the disease and these processes contribute to and/or exacerbate the nigro-striatal degeneration. In addition, the experimental models discussed here have also provided strong evidence that these pathways are an important link between the familial and sporadic causes of PD. 01 April 2013
Exercise attenuates levodopa-induced dyskinesia in 6-hydroxydopamine-lesioned micel-3,4-dihydroxyphenylalanine (l-DOPA) alleviates the motor symptoms of Parkinson's disease (PD), but its long-term use is associated with underirable dyskinesia. Authors now tested whether exercise can attenuate these l-DOPA-induced dyskinesia (LID). 01 April 2013
Major life events and development of major depression in Parkinson's disease patientsConclusions: Life events play an important role for onset of depression in patients with PD; an effect that seems to be modulated by social support and coping capacities and these factors may therefore be important to assess in order to identify patients with PD at high risk of depression and provide effective interventions. 01 April 2013
Somatosensory temporal discrimination threshold may help to differentiate patients with multiple system atrophy from patients wiThe aim of the study was to investigate whether the extent of STDT alterations differs between patients with parkinsonian type multiple system atrophy (MSA-P) and patients with Parkinson's disease (PD). Possible differences between the two groups may help to differentiate MSA-P from PD. 01 April 2013
Attenuated neural response to gamble outcomes in drug-naive patients with Parkinson's diseaseThe results show that the core regions of the meso-cortico-limbic dopaminergic system, including the ventral tegmental area, ventral striatum, and medial orbitofrontal cortex, are already significantly compromised in the early stages of the disease and that these deficits cannot be attributed to the contaminating effect of dopaminergic treatment. 01 April 2013
Extended-release carbidopa-levodopa in Parkinson's diseaseLevodopa with carbidopa is undoubtedly the gold standard of treatment for Parkinson's disease. But an initial spectacular benefit with this drug, known as the honeymoon period, is often compromised within a few years by the occurrence of disabling on-off fluctuations and dyskinesia. 01 April 2013
Progressive changes in a recognition memory network in Parkinson's diseaseIn a previous functional MRI (fMRI) study, the authors found that patients with Parkinson's disease (PD) presented with dysfunctions in the recruitment of recognition memory networks. They aimed to investigate the changes in these networks over time. 01 April 2013
Parkinson's disease: an update on pathogenesis and treatmentThis review aims to highlight the most relevant updates in the PD field, with emphasis on research that may help lead towards an improvement in the treatment of this condition. 01 April 2013
Transcranial sonography in patients with Parkinson's disease with glucocerebrosidase mutationsConclusions TCS findings in GBA-associated PD were consistent to those of patients with sporadic PD. 01 April 2013

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