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Measurement and diagnosis research papers

Mobile systems for monitoring Parkinson's diseaseIn this thesis, data from a mobile device test battery, collected during a three year clinical study, was used for the development and evaluation of methods. The data was gathered from a series of tests, consisting of selfassessments and motor tests (tapping and spiral drawing). 15 December 2013
Rest tremor suppression may separate essential from Parkinsonian rest tremorAuthors conclude that the assessment of the suppression of rest tremor during movement initiation is a simple and reliable tool to separate PT from rest tremor in ET also suggesting that the mechanisms of rest tremor in these two diseases are different. 01 July 2013
Catecholamines and Neurodegeneration in Parkinson's DiseaseFrom Diagnostic Marker to Aggregations of α-SynucleinHere, authors review findings relating to an early diagnostic marker for detecting degeneration of the peripheral sympathetic nerves, and propose the hypothesis that catecholamines cause alpha-synuclein to aggregate and play an important role in disease pathogenesis. 01 June 2013
Network modeling to identify new mechanisms and therapeutic targets for Parkinson's diseaseIn this article, the authors use genome-wide association study and linkage data derived from Parkinson's disease studies to illustrate how algorithms that use gene and protein interaction databases reveal subnetworks in biological systems that suggest mechanisms for disease progression. 01 June 2013
Atypical atypical parkinsonism: New genetic conditions presenting with features of PSP, CBD or MSA - A diagnostic guideIn this review, the goal is to make clinicians aware of these genetic disorders and provide clinical clues and syndromic associations, as well as investigative features, that may help in diagnosing these disorders. The correct identification of these patients has important clinical, therapeutic, and research implications. 29 May 2013
The Addenbrooke's Cognitive Examination for the differential diagnosis and longitudinal assessment of patients with parkinsonianAuthors propose the ACE-R, particularly the verbal fluency subscore, as a valuable contributor to the differential diagnosis of parkinsonian syndromes in the correct clinical context. The ACE-R may reflect disease progression in PD and CBD. 20 May 2013
Preceding pain symptoms and Parkinson's disease: a nationwide population-based cohort studyConclusions These findings support the hypothesis that pain is associated with PD in the pre-motor stage of the disease. Further research is needed to clarify the role of sensory system involvement in the pre-motor phase of PD. 17 May 2013
Mesencephalic area measured by transcranial sonography in the differential diagnosis of parkinsonismConclusions: Measurement of the mesencephalic area and the third ventricle width by TCS is a non-invasive, easily accessible technique that is useful in the differential diagnosis between PD and PSP, at least in the late stages of the disease. 16 May 2013
A novel bedside task to tap inhibitory dysfunction and fronto-striatal atrophy in Parkinson's diseaseConclusions: The ELF is a brief bedside task that efficiently detects inhibitory dysfunction in non-demented PD. The utility of this novel behavioural measure is further substantiated by its anatomical specificity for fronto-striatal inhibitory control regions. 15 May 2013
How to identify tremor dominant & postural instability/gait difficulty groups with the MDS unified PD rating scaleFormulas were developed to define tremor dominant (TD) and postural instability/gait difficulty (PIGD) phenotypes of Parkinson's Disease (PD) using the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS). 15 May 2013

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