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Measurement and diagnosis research papers
Objective characterization of daily living transitions in patients with Parkinson's disease using a single body-fixed sensor
Initial results suggest that body-fixed sensor-derived metrics of everyday transitions can characterize disease severity and differentiate mild PD patients from healthy older adults. Perhaps this approach can help with the integration of BFS into clinical care and the tracking of disease progression and the response to therapy.
23 May 2016
Disability Rating Scales in Parkinson's Disease: Critique and Recommendations
Conclusion: Many disability measures are available and recommended for application in PD. The Task Force does not recommend the development of a new scale. Selection of the most appropriate instrument for a particular objective requires consideration of the characteristics of each scale and the goals of the assessment.
19 May 2016
Alterations of putaminal shape in de novo Parkinson's disease
Conclusions: Shape analysis in de novo-PD patients suggested a progressive medial-to-lateral involvement of the putamina that paralleled an asymmetric-to-bilateral distribution of DA transporter depletion.
15 May 2016
Postural instability and gait are associated with severity and prognosis of Parkinson disease
Conclusions: In contrast to PIGD, which consistently was associated with greater severity of nondopaminergic symptoms, there was no evidence of a benign effect of tremor. Our findings do not support the use of the TD subtype as a prognostic trait in PD. The results showed that severity of PIGD is a useful indicator of severity and prognosis in PD by itself.
13 May 2016
Night-time sleep in Parkinson's disease the potential use of Parkinson's KinetiGraph: a prospective comparative study
This first PKG based study of night-time sleep in PD suggests that PKG could be used to provide an easy to use and rough evaluation of aspects of night-time sleep and one that could flag patients where polysomnography may be required. In sleepy PD patients for instance, quantity and quality PKG parameters correlate with different aspects of sleep such as insomnia, parasomnia and restless legs syndrome.
10 May 2016
Optimizing odor identification testing as quick and accurate diagnostic tool for Parkinson's disease
Conclusions Odor identification testing provides excellent diagnostic accuracy in the distinction of PD patients from controls and diagnostic mimics. A reduced set of eight odors could be used as a quick tool in the workup of patients presenting with parkinsonism and for PD risk indication.
09 May 2016
Tests of manual dexterity and speed in Parkinson's disease: Not all measure the same
Conclusions: Contactless 3D motion capture of finger tapping allowed an independent analysis of individual components of bradykinesia, demonstrating the amplitude decrement and maximum opening velocity as the most powerful discriminators between PD patients and controls.
07 May 2016
Monitoring of 30 marker candidates in early Parkinson disease as progression markers
Conclusions: Current CSF biomarkers and cognitive scales do not represent useful progression markers. However, sleep and imaging measures, and to some extent NMS, assessed using adequate scales, may be more informative markers to quantify progression.
06 May 2016
In vivo imaging of neuromelanin in Parkinson's disease using 18F-AV-1451 PET
The magnitude of the nigral signal loss was smaller than the decrease in striatal dopamine transporter signal measured by dopamine transporter single photon emission computed tomography. Study findings suggest a more severe loss of striatal nerve terminal function compared with neuronal cell bodies, in accordance with the post-mortem literature.
05 May 2016
Technology in Parkinson's disease: Challenges and opportunities
This article summarizes the work carried out by the task force toward identifying challenges and opportunities in the development of technologies with potential for improving the clinical management and the quality of life of individuals with PD.
29 April 2016
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