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Measurement and diagnosis research papers
Correlation of striatal dopamine transporter imaging with post mortem substantia nigra cell counts
Striatal dopamine transporter binding highly correlated with postmortem SN cell counts, confirming the validity of dopamine transporter imaging as an excellent in vivo marker of nigrostriatal dopaminergic degeneration.
22 July 2014
Abnormal MoCA and Normal Range MMSE scores in Parkinson disease without dementia: Cognitive and Neurochemical Correlates
Conclusion: PD subjects with normal range MMSE but abnormal MoCA scores had evidence of caudate nucleus dopaminergic denervation and mild cognitive changes, predominantly in executive function. The MoCA may be able to preferentially detect executive dysfunction compared to the MMSE, but the MoCA has limited diagnostic accuracy for PD-MCI, and should not be used alone to make this diagnosis.
21 July 2014
Flt3 ligand does not differentiate between Parkinsonian disorders
No validated biomarkers are available for early and accurate diagnosis of multiple system atrophy and other parkinsonian disorders. It has been reported that flt3 ligand levels in cerebrospinal fluid could clearly differentiate patients with Parkinson's disease from patients with multiple system atrophy, with 99% sensitivity and 95% specificity.
16 July 2014
Novel AAV-Based Rat Model of Forebrain Synucleinopathy Shows Extensive Pathologies & Progressive Loss of Cholinergic Interneuron
This study provides a novel rat model of progressive cortical synucleinopathy, showing for the first time that cholinergic interneurons are vulnerable to α-synuclein over-expression. This animal model provides a powerful new tool for studies of neuronal degeneration in conditions of widespread cortical α-synuclein pathology, such as DLB, as well an attractive model for the exploration of novel biomarkers.
07 July 2014
Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson's disease
In conclusion, study findings cast doubt on the pathogenic role of α-synuclein aggregates in elderly, but do suggest that the severity of neurodegeneration and local burden of α-synuclein pathological conditions are closely coupled during disease progression in Parkinson's disease.
03 July 2014
Genetic assessment of familial and early-onset Parkinson's disease in a Greek population
Results: In total, five patients (4.5% of the whole population) were identified with the A53T SNCA mutation, two with a heterozygote dosage mutation and one with a heterozygote point mutation in the Parkin gene, and seven patients (10.3% of the familial cohort) with GBA gene mutations.
01 July 2014
Development and validation of a new screening questionnaire for dysphagia in early stages of Parkinson's disease
The two-phased project comprised the questionnaire, diagnostic scales construction (N=105), and a validation study (N=82). Data for the project were gathered from PD patients at a German Movement Disorder Center. F
30 June 2014
The prevalence of Parkinson's disease: A systematic review and meta-analysis
Authors sought to synthesize studies on the prevalence of PD to obtain an overall view of how the prevalence of this disease varies by age, by sex, and by geographic location.
28 June 2014
Low clinical diagnostic accuracy of early vs advanced Parkinson disease
Using neuropathologic findings of PD as the gold standard, this study establishes the novel findings of only 26% accuracy for a clinical diagnosis of PD in untreated or not clearly responsive subjects, 53% accuracy in early PD responsive to medication (85% diagnostic accuracy of longer duration, medication-responsive PD.
27 June 2014
Cardiac stress test is normal in pre-motor Parkinson's disease
Authors retrospectively reviewed treadmill ergometric tests of a large cohort (n = 16,841) between 2000 and 2012, that attended the Executive Screening Survey (ESS) at Sheba Medical Center. Heart rate and blood pressure profiles as well as exercise capacity were compared between subjects who later developed PD and age- and sex-matched subjects (ratio 1:2) who did not.
20 June 2014
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