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Measurement and diagnosis research papers

  • Pulse graph Quantitative wearable sensors for objective assessment of Parkinson's diseaseThis review discusses promising wearable technology, addresses which parameters should be prioritized in such assessment strategies, and reports about studies that have already investigated daily life issues in PD using this new technology. 12 September 2013
  • Chart Graph Rankin scale as a potential measure of global disability in early Parkinson's diseaseAuthors conducted an exploratory analysis of the utility of the modified Rankin Scale (mRS) as a global measure of disability in early Parkinson's diesase (PD) using the baseline data from a large cohort of PD patients enrolled in a longitudinal study of creatine. 01 September 2013
  • Brain skeleton activity Is there a need to redefine Parkinson's disease?A key challenge in PD research, therefore, is to better characterize markers for the 'preclinical' stages of the illness. Development of PD criteria by combining such markers allowing for an early diagnosis and intervention could pave the way for the design and implementation of future disease modification trials. 01 September 2013
  • Survey Handwriting as an objective tool for Parkinson's disease diagnosisIn this pilot study authors identified two simple short and routine writing tasks which differentiate PD patients from healthy controls. These writing tasks have future potential as cost-effective, fast and reliable biomarkers for PD. 01 September 2013
  • Brain activity Handwriting as an objective tool for Parkinson's disease diagnosisIn this pilot study we identified two simple short and routine writing tasks which differentiate PD patients from healthy controls. These writing tasks have future potential as cost-effective, fast and reliable biomarkers for PD. 01 September 2013
  • Neuron Biomarkers in Parkinson's disease (recent update)This brief review describes the merits and limitations of recently discovered biomarkers and proposes coenzyme Q10, mitochondrial ubiquinone-NADH oxidoreductase, melatonin, α-synculein index, Charnoly body, and metallothioneins as novel biomarkers to confirm PD diagnosis for early and effective treatment of PD. 01 September 2013
  • Brain scan A novel bedside task to tap inhibitory dysfunction and fronto-striatal atrophy in Parkinson's diseaseConclusions: The ELF is a brief bedside task that efficiently detects inhibitory dysfunction in non-demented PD. The utility of this novel behavioural measure is further substantiated by its anatomical specificity for fronto-striatal inhibitory control regions. 01 September 2013
  • Man with stick Clinical and posturographic correlates of falling in Parkinson's diseaseThe purpose of this study was to determine the efficacy of clinical tests, balance scales, and stable-platform posturography in detecting postural instability and discriminating between fallers and non-fallers in a home-dwelling PD cohort. 15 August 2013
  • Brain activity Recent developments in biomarkers in Parkinson diseaseStrategies are being developed to apply recent advances in our understanding of the cause of Parkinson disease to the development of biomarkers that will enable the identification of at-risk individuals, enable early diagnosis and reflect the progression of disease. The latter will be particularly important for the testing of disease-modifying therapies. This review summarizes recent advances in Parkinson disease biomarker development. 01 August 2013
  • Brain scan Mesencephalic area measured by transcranial sonography in the differential diagnosis of parkinsonismConclusions: Measurement of the mesencephalic area and the third ventricle width by TCS is a non-invasive, easily accessible technique that is useful in the differential diagnosis between PD and PSP, at least in the late stages of the disease. 01 August 2013
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