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Research papers


Measurement and diagnosis research papers

  • Brain scan Parkinson's disease patients show reduced cortical-subcortical sensorimotor connectivityThe purpose of this study was to measure anatomical and functional connectivity in groups of PD patients and controls to determine whether connectivity deficits within the corticobasal ganglia thalamocortical system could be attributed to PD, particularly in sensorimotor connections. 15 April 2013
  • MRI Magnetic resonance imaging: A biomarker for cognitive impairment in Parkinson's disease?In this review, the ability to compare studies was limited by the heterogeneity of study populations, cognitive testing methods, and imaging protocols. Future work should adopt agreed scan protocols, should be adequately powered, and should use carefully phenotyped patients to fully maximize the contribution of MRI as a biomarker for PDD. 15 April 2013
  • Man with stick A systematic review of biomarkers for disease progression in Parkinson's diseaseAuthors found insufficient evidence to recommend the use of any biomarker for disease progression in PD clinical trials, which may simply reflect the poor quality of research in this area. They therefore present a provisional 'roadmap' for conducting future disease progression biomarker studies, and recommend new quality criteria by which future studies may be judged. 12 April 2013
  • Brain Parkinson's disease redefinedParkinson's disease can be regarded as a generational illness, not only because of its incidence in elderly people, but also because of the changing conceptualisation of the disorder across generations of doctors and researchers. Disease conceptualisation has changed along three epochs since the initial description of the shaking palsy by James Parkinson, and after Charcot's elaboration on the clinical phenotype. 09 April 2013
  • Brain activity Transcranial sonography in patients with Parkinson's disease with glucocerebrosidase mutationsConclusions TCS findings in GBA-associated PD were consistent to those of patients with sporadic PD. 01 April 2013
  • Quality of Life Friends Couple walking in woods The PDQ-Carer: Development and validation of a summary index scoreThe analyses undertaken here indicate that data from the PDQ-Carer can be presented in summary form. The index will provide an overall indication of the impact of caring. Furthermore, the single index reduces the number of statistical comparisons, and hence the role of chance, when exploring data from the PDQ-Carer. 01 April 2013
  • Brain Somatosensory temporal discrimination threshold may help to differentiate patients with multiple system atrophy from patients wiThe aim of the study was to investigate whether the extent of STDT alterations differs between patients with parkinsonian type multiple system atrophy (MSA-P) and patients with Parkinson's disease (PD). Possible differences between the two groups may help to differentiate MSA-P from PD. 01 April 2013
  • Chart Graph Which Dyskinesia Scale Best Detects Treatment Response?This study resolves 2 major issues useful for future testing of new antidyskinesia treatments: among tested scales, the UDysRS, having both subjective and objective dyskinesia ratings, is superior for detecting treatment effects; and the magnitude of the UDysRS effect size from amantadine sets a clear standard for comparison for new agents. 15 March 2013
  • Neuron Deriving dopaminergic neurons for clinical use. A practical approachNew small molecules that regulate the step-wise differentiation of human pluripotent stem cells into dopaminergic neurons have been identified. The steroid, guggulsterone, was found to be the most effective inducer of neural stem cells into dopaminergic neurons. These neurons are extensively characterized and shown to be functional. 15 March 2013
  • Chart Graph Validation of the Modified Fatigue Impact Scale in Parkinson's diseaseConclusion: Overall, this study demonstrates that the MFIS is a valid multidimensional measure that can be used to evaluate the impact of fatigue on cognitive and physical/social functioning in PD patients without dementia. 01 March 2013
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