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Measurement and diagnosis research papers
Multifunctional wearable devices for diagnosis and therapy of movement disorders
Here authors describe materials, mechanics and designs for multifunctional, wearable-on-the-skin systems that address these challenges via monolithic integration of nanomembranes fabricated with a top-down approach, nanoparticles assembled by bottom-up methods, and stretchable electronics on a tissue-like polymeric substrate.
30 March 2014
Hyposmia and cardiovascular dysautonomia correlatively appear in early-stage Parkinson's disease
Results demonstrate that extensive components of the cardiovascular sympathetic system as well as the olfactory system are correlatively impaired in the early stage of PD, suggesting that degeneration of broad aspects of the cardiovascular sympathetic system occurs concurrently with olfactory system degeneration during the premotor phase of PD.
17 March 2014
Dopamine receptor mapping with PET imaging in Parkinson's disease
In this article authors aim to review the role of PET imaging in understanding the postsynaptic dopaminergic mechanisms in PD. PET studies have allowed us to gain important insights into the functions of the dopaminergic system, the mechanisms of drug-induced motor and non-motor complications, and the placebo effect in PD.
15 March 2014
Cerebrospinal Fluid α-Synuclein Predicts Cognitive Decline in Parkinson's Disease Progression in the DATATOP Cohort
Study authors examined clinical data and α-synuclein in >300 unmedicated patients with PD who participated in the deprenyl and tocopherol antioxidative therapy of parkinsonism (DATATOP) study, with up to 8 years of follow-up.
13 March 2014
Submandibular gland needle biopsy for the diagnosis of Parkinson disease
This study demonstrates the feasibility of performing needle core biopsies of the submandibular gland in living patients with PD to assess LTS. Although this was a small study, this tissue biopsy method may be important for tissue confirmation of PD in patients being considered for invasive procedures and in research studies of other PD biomarkers.
11 March 2014
Transcranial sonography and [18F]fluorodeoxyglucose positron emission tomography for differential diagnosis of parkinsonism...
Conclusions: FDG-PET and TCS show comparable accuracies for differential diagnosis of neurodegenerative parkinsonism. This preliminary study supports the use of TCS and warrants further prospective validation.
06 March 2014
Clinician Versus Machine: Reliability and Responsiveness of Motor Endpoints in Parkinson's Disease
Conclusions: The Kinesia portable kinematic system can provide greater test-retest reliability and sensitivity to change than conventional clinical ratings for measuring bradykinesia, hypokinesia, and dysrhythmia in PD patients.
05 March 2014
Parkinson's disease with and without preceding essential tremor-similar phenotypes: a pilot study
The fact that non-motor symptoms were similar in ET-PD gives rise to the hypothesis that also the prodromal phase of PD is similar in ET patients later developing classical PD compared to individuals developing PD without preceding ET.
04 March 2014
Postural sway in idiopathic rapid eye movement sleep behavior disorder: A potential marker of prodromal Parkinsons disease
Study results indicate that idiopathic RBD patients, especially with abnormal stereopsis, have subtle signs of postural instability under challenging conditions. Postural sway performance may serve as a biological marker for prodromal PD.
03 March 2014
Quantitative Electromyographic Analysis of Reaction Time to External Auditory Stimuli in Drug-Naïve Parkinson's Disease
n conclusion, greater RT is the characteristic motor features of PD and it could be used as a sensitive tool for motor function assessment in PD patients. Further investigations are required to clarify the clinical impact of the RT on the activity of daily living of patients with PD.
02 March 2014
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