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Measurement and diagnosis research papers

Clinical and posturographic correlates of falling in Parkinson's diseaseThe purpose of this study was to determine the efficacy of clinical tests, balance scales, and stable-platform posturography in detecting postural instability and discriminating between fallers and non-fallers in a home-dwelling PD cohort. 22 April 2013
Gray matter atrophy distinguishes between Parkinson disease motor subtypesObjective: To assess differences in gray matter (GM) atrophy between 2 Parkinson disease (PD) subtypes: the tremor dominant (TD) subtype and the postural instability gait difficulty (PIGD) subtype. 16 April 2013
Parkinson's disease patients show reduced cortical-subcortical sensorimotor connectivityThe purpose of this study was to measure anatomical and functional connectivity in groups of PD patients and controls to determine whether connectivity deficits within the corticobasal ganglia thalamocortical system could be attributed to PD, particularly in sensorimotor connections. 15 April 2013
Designing a new scale to measure anxiety symptoms in Parkinson's disease: item selection based on canonical correlation analysisConclusions: BAI is heavily focused on panic symptoms, whilst HARS is more focused towards generalized anxiety symptoms. The new scale should include additional components in order to assess both episodic and persistent anxiety as well as items for evaluation of avoidance behaviour. 14 April 2013
A systematic review of biomarkers for disease progression in Parkinson's diseaseAuthors found insufficient evidence to recommend the use of any biomarker for disease progression in PD clinical trials, which may simply reflect the poor quality of research in this area. They therefore present a provisional 'roadmap' for conducting future disease progression biomarker studies, and recommend new quality criteria by which future studies may be judged. 12 April 2013
Structural and molecular interrogation of intact biological systemsHere authors address this challenge with a method (termed CLARITY) for the transformation of intact tissue into a nanoporous hydrogel-hybridized form (crosslinked to a three-dimensional network of hydrophilic polymers) that is fully assembled but optically transparent and macromolecule-permeable. 10 April 2013
Determinants of delayed diagnosis in Parkinson's diseaseThe early and accurate diagnosis of Parkinson's disease (PD) is the first step towards optimal patient management. The aim of this study was to investigate the major determinants of delayed diagnosis in PD. 10 April 2013
Parkinson's disease redefinedParkinson's disease can be regarded as a generational illness, not only because of its incidence in elderly people, but also because of the changing conceptualisation of the disorder across generations of doctors and researchers. Disease conceptualisation has changed along three epochs since the initial description of the shaking palsy by James Parkinson, and after Charcot's elaboration on the clinical phenotype. 09 April 2013
Somatosensory temporal discrimination threshold may help to differentiate patients with multiple system atrophy from patients wiThe aim of the study was to investigate whether the extent of STDT alterations differs between patients with parkinsonian type multiple system atrophy (MSA-P) and patients with Parkinson's disease (PD). Possible differences between the two groups may help to differentiate MSA-P from PD. 01 April 2013
Transcranial sonography in patients with Parkinson's disease with glucocerebrosidase mutationsConclusions TCS findings in GBA-associated PD were consistent to those of patients with sporadic PD. 01 April 2013

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