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Research papers


Measurement and diagnosis research papers

  • Movement Disorders Volume 31 Issue 4 The BioFIND study: Characteristics of a clinically typical Parkinson's disease biomarker cohortThe study cohort provides a valuable resource for biomarker discovery and validation in PD. Clinical data and biospecimens, available through The Michael J. Fox Foundation for Parkinson's Research and the National Institute of Neurological Disorders and Stroke, can serve as a platform for discovering biomarkers in clinically typical PD and comparisons across PD's broad and heterogeneous spectrum. 26 April 2016
  • Journal of Neurology Voxel-based meta-analysis of gray matter volume reductions associated with cognitive impairment in Parkinson's diseaseGMV reductions in the frontal-limbic-temporal regions were main features of cognitive decline in PD. Unilateral-to-bilateral development of GMV reduction in the frontal-limbic-temporal regions is a possible indicator for PD-MCI to PDD progression, whereas significant hippocampal GMV reduction may not be a marker for early cognitive decline in PD. 25 April 2016
  • Parkinsonism & Related Disorders Volume 25 How stable are Parkinson's disease subtypes in de novo patients: Analysis of the PPMI cohort?Conclusions: TD versus PIGD subtype classification has substantial variability over first year in PD de novo cohort specifically for PIGD subtype. Dopaminergic therapy does not impact the change of the PD subtype. This instability has to be taken into consideration specifically when establishing correlations with the biomarkers and for long term prognostication. 23 April 2016
  • Movement Disorders Volume 31 Issue 4 Aberrant nigral diffusion in Parkinson's disease: A longitudinal diffusion tensor imaging studyRegion-of-interest analysis demonstrated that at baseline, PD patients and controls did not differ in regard to diffusion indices in any region assessed. A significant difference of nigral fractional anisotropy and mean diffusivity between controls and PD patients at follow-up was detected and confirmed with longitudinal analysis within PD patients. Alterations in striatal regions were not detected in either group or over time. 22 April 2016
  • Movement Disorders Volume 31 Issue 3 Patterns of Cortical Thinning in Nondemented Parkinson's Disease PatientsConclusions: Three cortical atrophy subtypes were identified in nondemented Parkinson's disease patients: (1) parieto-temporal pattern of atrophy with worse cognitive performance, (2) occipital and frontal cortical atrophy and younger disease onset, and (3) patients without detectable cortical atrophy. These findings may help identify prognosis markers in Parkinson's disease. 20 April 2016
  • Movement Disorders Volume 31 Issue 4 Time on timing: Dissociating premature responding from interval sensitivity in Parkinson's diseaseIn this study, 18 PD patients and 19 age-matched controls completed 2 temporal discrimination tasks (bisection and trisection) and a baseline reaction-time task. Timing sensitivity and decision-making processes were quantified by response and response time. An extended version of the modified difference model was used to examine the precision of time representation and the modulation of response time by stimulus ambiguity. 19 April 2016
  • JNNP Volume 86 Defining and validating a short form Montreal Cognitive Assessment (s-MoCA) for use in neurodegenerative diseaseResults 8 MoCA items with high item discrimination and appropriate difficulty were identified for use in a short form (s-MoCA). The s-MoCA was highly correlated with the original MoCA, showed robust diagnostic classification and cross-validation procedures substantiated these items. 12 April 2016
  • Neurology Age at onset and Parkinson disease phenotypeConclusions: Although the presentation of PD symptoms is similar across age subgroups, the severity of motor and nonmotor features, the impairment of striatal binding, and the levels of CSF biomarkers increase with age at onset. The variability of imaging and nonimaging biomarkers in patients with PD at different ages could hamper the results of future clinical trials. 12 April 2016
  • Movement Disorders Volume 31 Issue 3 Cortical phosphorylated α-Synuclein levels correlate with brain wave spectra in Parkinson's diseaseStudy data show an association between increased phosphorylation of α-synuclein and the abnormal EEG signatures of cognitive decline. Results suggest that quantitative EEG may provide an in vivo approximation of phosphorylated α-synuclein in PD cortex. This adds to previous evidence that quantitative EEG measures can be considered valid biomarkers of PD cognitive decline. 08 April 2016
  • Parkinson's Disease Reliability of Three Disability Scales for Detection of Independence Loss in Parkinson's DiseaseConclusion: Both the disease-specific HY staging and SE scale and the generic Barthel ADL index are suboptimal tools for assessing independence loss in PD. Clinical interview should be the assessment of choice in studies of dependency. 06 April 2016
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