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Measurement and diagnosis research papers
Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson's disease
In conclusion, study findings cast doubt on the pathogenic role of α-synuclein aggregates in elderly, but do suggest that the severity of neurodegeneration and local burden of α-synuclein pathological conditions are closely coupled during disease progression in Parkinson's disease.
03 July 2014
Genetic assessment of familial and early-onset Parkinson's disease in a Greek population
Results: In total, five patients (4.5% of the whole population) were identified with the A53T SNCA mutation, two with a heterozygote dosage mutation and one with a heterozygote point mutation in the Parkin gene, and seven patients (10.3% of the familial cohort) with GBA gene mutations.
01 July 2014
Development and validation of a new screening questionnaire for dysphagia in early stages of Parkinson's disease
The two-phased project comprised the questionnaire, diagnostic scales construction (N=105), and a validation study (N=82). Data for the project were gathered from PD patients at a German Movement Disorder Center. F
30 June 2014
The prevalence of Parkinson's disease: A systematic review and meta-analysis
Authors sought to synthesize studies on the prevalence of PD to obtain an overall view of how the prevalence of this disease varies by age, by sex, and by geographic location.
28 June 2014
Low clinical diagnostic accuracy of early vs advanced Parkinson disease
Using neuropathologic findings of PD as the gold standard, this study establishes the novel findings of only 26% accuracy for a clinical diagnosis of PD in untreated or not clearly responsive subjects, 53% accuracy in early PD responsive to medication (85% diagnostic accuracy of longer duration, medication-responsive PD.
27 June 2014
Cardiac stress test is normal in pre-motor Parkinson's disease
Authors retrospectively reviewed treadmill ergometric tests of a large cohort (n = 16,841) between 2000 and 2012, that attended the Executive Screening Survey (ESS) at Sheba Medical Center. Heart rate and blood pressure profiles as well as exercise capacity were compared between subjects who later developed PD and age- and sex-matched subjects (ratio 1:2) who did not.
20 June 2014
Imaging insights into basal ganglia function, Parkinson's disease, and dystonia
Radionuclide imaging is the best way to detect and monitor dopamine deficiency, and will probably continue to be the best biomarker for assessment of the effects of disease-modifying therapies. However, advances in magnetic resonance enable the separation of patients with Parkinson's disease from healthy controls, and show great promise for differentiation between Parkinson's disease and other akinetic-rigid syndromes.
19 June 2014
Differentiating drug-induced parkinsonism from Parkinson's disease: An update on non-motor symptoms and investigations
Authors performed a review to ascertain whether assessment of non-motor symptoms, or use of ancillary investigations, namely dopamine transporter imaging, transcranial sonography of the substantia nigra, and scintigraphy for myocardial sympathetic innervation, can be recommended to distinguish between these conditions.
05 June 2014
Clinical evolution of Parkinson's disease and prognostic factors affecting motor progression: 9-year follow-up study
Study results show that, when measured clinically, motor progression was non-linear and that it occurred in distinct phases, all of which were affected by baseline demographic and clinical variables such as gender, age at diagnosis, disease subtype, cognitive status and baseline motor score.
02 June 2014
Transcranial sonography and [18F]fluorodeoxyglucose positron emission tomography for differential diagnosis of parkinsonism...
Conclusions: FDG-PET and TCS show comparable accuracies for differential diagnosis of neurodegenerative parkinsonism. This preliminary study supports the use of TCS and warrants further prospective validation.
01 June 2014
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