Research papers

Search for

Measurement and diagnosis research papers

Catecholamines and Neurodegeneration in Parkinson's DiseaseFrom Diagnostic Marker to Aggregations of α-SynucleinHere, authors review findings relating to an early diagnostic marker for detecting degeneration of the peripheral sympathetic nerves, and propose the hypothesis that catecholamines cause alpha-synuclein to aggregate and play an important role in disease pathogenesis. 25 March 2013
High-resolution tracking of motor disorders in Parkinson's disease during unconstrained activityThe objective of this study was to validate disease-related metabolic brain patterns for Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy. 20 March 2013
Risk factors for hallucinations in Parkinson's disease: Results from a large prospective cohort studyThese findings lend support to the notion that hallucinations in PD are caused by a combination of risk factors that are associated with (the interaction between) older age and more advanced disease. The identification of female sex as a risk factor for developing of hallucinations in PD is a new finding and should be verified in future studies. 20 March 2013
Questionnaire-based diagnosis of REM sleep behavior disorder in Parkinson's diseaseRapid eye movement (REM) sleep behavior disorder (RBD) is present in around 40% of Parkinson's disease (PD) patients. Definitive diagnosis requires a polysomnogram, but that is costly, time intensive, and not practical for large-scale studies. Therefore, the authors assessed using a questionnaire-based diagnostic approach. 20 March 2013
Utility of transcranial sonography in the diagnosis of drug-induced parkinsonism: a prospective studyConclusions: Although in this study statistically significant differences were not found between the transcranial sonography characteristics of subclinical drug-exacerbated parkinsonism and iatrogenic parkinsonism patients, we believe that transcranial sonography is a valid technique for diagnosis of drug-induced parkinsonism. 16 March 2013
Utility of transcranial sonography in the diagnosis of drug-induced parkinsonism: a prospective studyAlthough in this study statistically significant differences were not found between the transcranial sonography characteristics of subclinical drug-exacerbated parkinsonism and iatrogenic parkinsonism patients, we believe that transcranial sonography is a valid technique for diagnosis of drug-induced parkinsonism. 16 March 2013
Deriving dopaminergic neurons for clinical use. A practical approachNew small molecules that regulate the step-wise differentiation of human pluripotent stem cells into dopaminergic neurons have been identified. The steroid, guggulsterone, was found to be the most effective inducer of neural stem cells into dopaminergic neurons. These neurons are extensively characterized and shown to be functional. 15 March 2013
Which Dyskinesia Scale Best Detects Treatment Response?This study resolves 2 major issues useful for future testing of new antidyskinesia treatments: among tested scales, the UDysRS, having both subjective and objective dyskinesia ratings, is superior for detecting treatment effects; and the magnitude of the UDysRS effect size from amantadine sets a clear standard for comparison for new agents. 15 March 2013
Clinical utility of dopamine transporter single photon emission CT (DaT-SPECT) with (123I) ioflupane in diagnosis of ....This review was undertaken to clarify the utility of DaT-SPECT imaging with (123I)ioflupane (DaTSCAN or DaTscan or (123I)FP-CIT) in assisting practitioners in their clinical decision making by visualising the dopamine transporter in parkinsonian cases. 13 March 2013
Validation of parkinsonian disease-related metabolic brain patternsResults: Disease-related metabolic brain patterns for these parkinsonian disorders were identified. Validation showed that these patterns were highly discriminative of the 3 disorders. 11 March 2013

Page: [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [+11]

[ « Previous | Next » ]