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Research papers


Measurement and diagnosis research papers

  • Brain skeleton activity Subcortical grey matter changes in untreated, early stage Parkinson's disease without dementiaResults suggest that untreated, early stage PD without dementia is associated with volume reduction and shape deformation of subcortical grey matter, but not with cortical grey matter reduction. Study findings of structural changes in the posterolateral putamen and ventromedial putamen/nucleus accumbens could provide neuroanatomical basis for the involvement of motor and limbic striatum, further implicating motor and non-motor symptoms in PD, respectively. Early hippocampal involvement might be related to t 01 June 2014
  • MRI Resting-state fMRI study on drug-naive patients with Parkinson's disease and with depressionThis study demonstrates that PD-Dep patients are characterised by increased regional spontaneous neural activity in the orbitofrontal area and decreased functional integration within the prefrontal-limbic network. 01 June 2014
  • MRI MR Imaging of the Substantia Nigra at 7 T Enables Diagnosis of Parkinson DiseaseConclusion: MR imaging at 7-T allows a precise characterization of the SN and visualization of its inner organization. Three-dimensional multiecho susceptibility-weighted images can be used to accurately differentiate healthy subjects from PD patients, which provides a novel diagnostic opportunity. 01 June 2014
  • Neuron Measuring Disease Progression in Early Parkinson Disease - The National Institutes of Health Exploratory Trials (NET-PD) experieIn early PD, the UPDRS Part II score and Part III score and the Schwab and England Independence Scale score can be used to measure disease progression, whereas the 39-item Parkinson's Disease Questionnaire and summary index, Total Functional Capacity scale, and the 12-item Short Form Health Survey Physical Summary and Mental Summary are not sensitive to change. 01 June 2014
  • Survey Clinician Versus Machine: Reliability and Responsiveness of Motor Endpoints in Parkinson's DiseaseConclusions: The Kinesia portable kinematic system can provide greater test-retest reliability and sensitivity to change than conventional clinical ratings for measuring bradykinesia, hypokinesia, and dysrhythmia in PD patients. 01 June 2014
  • Clasped hands Can Objective Measurements Improve Treatment Outcomes in Parkinson's Disease?Authors conclude that there is a clear need for continuous objective measures of dyskinesia and bradykinesia while patients go about their normal daily activities. The benefit of measurement would be greatest if these measures were directed at treating fluctuations. 01 June 2014
  • Clasped hands Sleep Disorders in Parkinson's DiseaseManagement of sleep disorders in PD patients usually starts with optimization of (dopaminergic) antiparkinsonian therapy followed by specific treatment of the sleep disturbances. Aside from these clinical issues of sleep disorders in PD, the concept of REM-sleep behaviour disorder (RBD) as an early sign for emerging neurodegenerative diseases is of pivotal interest for future research on biomarkers and neuroprotective treatment strategies of neurodegenerative diseases, and particularly PD. 20 May 2014
  • Brain scan Longitudinal follow-up of SWEDD subjects in the PRECEPT StudyThese results indicate that subjects identified as having a SWEDD, with DAT imaging within the normal range, have minimal evidence of clinical or imaging PD progression. These data strongly suggest that SWEDD subjects are unlikely to have idiopathic PD. 20 May 2014
  • DNA Prevalence of cancer in Parkinson's disease related to R1441G and G2019S mutations in LRRK2. In both the carrier and iPD groups, cancers were diagnosed after the onset of PD. PD patients had a similar prevalence of cancer to control subjects. There was no increased association between G2019S or R1441G mutations and any type of cancer. Although there was a higher prevalence of hematological cancers in the R1441G group, the low number of such cancers overall makes this finding of uncertain significance. 15 May 2014
  • Chart Graph Evaluation of mild cognitive impairment subtypes in Parkinson's diseaseSeparation of cognitive subtypes based on the current PD-MCI criteria, or via statistical methods, may not provide sufficient information to describe distinct PD groups. Future efforts to validate the PD-MCI criteria and identify combinations of genetic or other risk factors for cognitive impairment are warranted. 15 May 2014
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