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Measurement and diagnosis research papers

Clinical utility of dopamine transporter single photon emission CT (DaT-SPECT) with (123I) ioflupane in diagnosis of ....This review was undertaken to clarify the utility of DaT-SPECT imaging with (123I)ioflupane (DaTSCAN or DaTscan or (123I)FP-CIT) in assisting practitioners in their clinical decision making by visualising the dopamine transporter in parkinsonian cases. 13 March 2013
Validation of parkinsonian disease-related metabolic brain patternsResults: Disease-related metabolic brain patterns for these parkinsonian disorders were identified. Validation showed that these patterns were highly discriminative of the 3 disorders. 11 March 2013
Demographic and motor features associated with the occurrence of neuropsychiatric and sleep complications of Parkinson's diseaseAuthors conclude that measuring cortical thickness can be useful in assessing disease stage and cognitive impairment in patients with PD. In addition, cortical thickness may be useful in identifying dementia in PD. 05 March 2013
Is R2* a New MRI Biomarker for the Progression of Parkinson's Disease? A Longitudinal Follow-UpResults suggest that R2* MRI follow-up could be an interesting tool for individual assessment of neurodegeneration due to PD, and also be useful for testing the efficiency of disease-modifying treatments. 01 March 2013
Validation of the Modified Fatigue Impact Scale in Parkinson's diseaseConclusion: Overall, this study demonstrates that the MFIS is a valid multidimensional measure that can be used to evaluate the impact of fatigue on cognitive and physical/social functioning in PD patients without dementia. 01 March 2013
Dual task performance in Parkinson disease: A sensitive predictor of impairment and disabilityConclusion: This suggests that subjects prioritize gait performance at the expense of cognitive performance, and that DT word generation may be a sensitive indicator of early PD impairment and disability. 01 March 2013
How precise are activities of daily living scales for the diagnosis of Parkinson's disease dementia? A pilot studyConclusions: Standardized activities of daily living assessments like the Pill Questionnaire accompanied by neuropsychological testing can be a helpful tool for the diagnosis of PDD. Further studies are needed to verify these first results in larger cohorts. 01 March 2013
Performance of a shortened Scale for Assessment of Positive Symptoms for Parkinson's disease psychosisConclusions: The shortened Scale for Assessment of Positive Symptoms for Parkinson's disease retains the reliability, sensitivity to change, and effect size of the larger scale while reducing administration time and, more importantly, score variability. The scale is an effective outcome measure for use in clinical trials. 01 March 2013
Move for Change Part II: a European survey evaluating the impact of the EPDA Charter for people with Parkinson's diseaseConclusions: These data demonstrate the challenges faced by PD patients in accessing the adequate care and support required throughout the course of their disease. These findings can assist HCPs and policymakers in improving access to support services for patients and their families across Europe. 01 March 2013
Magnetic resonance imaging: A biomarker for cognitive impairment in Parkinson's disease?In this review, the ability to compare studies was limited by the heterogeneity of study populations, cognitive testing methods, and imaging protocols. Future work should adopt agreed scan protocols, should be adequately powered, and should use carefully phenotyped patients to fully maximize the contribution of MRI as a biomarker for PDD. 28 February 2013

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