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Measurement and diagnosis research papers

Rapid eye movement sleep behavior disorder in Parkinson's disease: Magnetic resonance imaging studyConclusions: Rapid eye movement sleep behavior disorder was associated with subtle changes in white matter integrity and grey matter volume in patients with early Parkinson's disease. 28 February 2013
Plasma apolipoprotein A1 as a biomarker for parkinson's diseaseInterpretation: Lower ApoA1 levels correlate with dopaminergic system vulnerability in symptomatic PD patients and in asymptomatic individuals with physiological reductions in dopamine transporter density consistent with prodromal PD. Plasma ApoA1 may be a new biomarker for PD risk 27 February 2013
How to identify tremor dominant & postural instability/gait difficulty groups with the MDS unified PD rating scaleFormulas were developed to define tremor dominant (TD) and postural instability/gait difficulty (PIGD) phenotypes of Parkinson's Disease (PD) using the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS). 13 February 2013
Olfaction and imaging biomarkers in premotor LRRK2 G2019S-associated Parkinson diseaseIndependently of age at examination, the most frequently altered premotor biomarker in LRRK2 G2019S-associated PD was SN hyperechogenicity, whereas abnormal DaT-SPECT predominated in older, unaffected mutation carriers. 12 February 2013
Olfactory loss as a supporting feature in the diagnosis of Parkinson's disease: a pragmatic approachOlfactory measurement is easy, cheap and now easily available in a number of tests, and olfactory assessment at different stages of parkinsonism should be used as a diagnostic aid for idiopathic PD and would enhance the diagnostic accuracy of iPD when used in conjunction with the UK Parkinson's disease society Brain Bank supportive criteria for diagnosis of idiopathic Parkinson's disease. 03 February 2013
Substantia Nigra Volume Loss Before Basal Forebrain Degeneration in Early Parkinson DiseaseStudy results support the proposed neuropathological trajectory in PD and establish novel multispectral methods as MR imaging biomarkers for tracking the degeneration of the SNc and BF. 01 February 2013
Potential reliability and validity of a modified version of the UPDRS that could be administered remotelyResults: The mUPDRS versus standard motor UPDRS is cross-sectionally (ICC 0.92) and longitudinally (ICC 0.92) reliable for both treatment groups. High internal consistencies were also observed (α 0.96). The mUPDRS had high concurrent validity with the standard UPDRS at both time points and longitudinally (r 0.93, p < 0.0001). 01 February 2013
Rest energy expenditure in Parkinson's disease: Role of disease progression and dopaminergic therapyThis cross-sectional study aimed to ascertain the relationship between rest energy expenditure (REE), PD duration, Hoehn & Yahr (H&Y) stage, drug therapy and body mass index (BMI), in order to determine possible predictors of weight loss. 01 February 2013
Screening hypersexuality in Parkinson's disease in everyday practiceObjective: The purpose of this study was to develop a short and reliable measure of hypersexuality that could be used in everyday practice in patients with Parkinson's disease (PD). 01 February 2013
Validating an objective video-based dyskinesia severity score in Parkinson's disease patientsThe authors have developed a semi-automatic video-based objective dyskinesia quantifying measure called the severity score (SVS) that was evaluated on 35 patient videos. They present a study to evaluate the utility of our severity score and compare its performance to clinical ratings of neurologists. 01 February 2013

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