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Research papers


Measurement and diagnosis research papers

  • American Journal of Epidemiology Trends in the Incidence of Parkinson Disease in the General Population The Rotterdam StudyAuthors investigated trends in the incidence of parkinsonism and Parkinson disease (PD) by comparing data from the first 2 subcohorts of the Rotterdam Study, a prospective, population-based cohort study (first subcohort: baseline 1990 with 10 years of follow-up; second subcohort, baseline 2000 with 10 years of follow-up). From the baseline years, authors observed differences in the second subcohort that were associated with a lower risk of PD for some but not all baseline risk factors. 01 June 2016
  • Neurology Next-generation profiling to identify the molecular etiology of Parkinson dementiaResults: Genes overexpressed in both disease states were involved with an immune response, whereas shared underexpressed genes functioned in signal transduction or as components of the cytoskeleton. Alternative splicing analysis produced a pattern of immune and RNA-processing disturbances. 01 June 2016
  • Journal of Parkinson's Disease Variation in Recent Onset Parkinson's Disease: Implications for Prodromal DetectionConclusions: Varying sensitivity levels, and age and phenotype selectivity, are found when different non-motor screening methods to detect prodromal PD are applied to an early clinical PD cohort. 26 May 2016
  • Parkinson's Disease Evaluation of Nonmotor Symptoms in Diagnosis of Parkinsonism and TremorAuthors ound that lower olfaction scores based on Sniffin Sticks testing combined with reports of depression and constipation are independent predictors for the diagnosis of the spectrum of Lewy body Parkinsonian disorders (LBPD). Parkinson's disease (PD) cannot be reliably clinically differentiated from other causes of Parkinsonism that share symptomatology and structural abnormalities. 22 May 2016
  • Movement Disorders Volume 31 Issue 1 Disability Rating Scales in Parkinson's Disease: Critique and RecommendationsConclusion: Many disability measures are available and recommended for application in PD. The Task Force does not recommend the development of a new scale. Selection of the most appropriate instrument for a particular objective requires consideration of the characteristics of each scale and the goals of the assessment. 19 May 2016
  • Movement Disorders Volume 31 Issue 5 Patterns of Cortical Thinning in Nondemented Parkinson's Disease PatientsConclusions: Three cortical atrophy subtypes were identified in nondemented Parkinson's disease patients: (1) parieto-temporal pattern of atrophy with worse cognitive performance, (2) occipital and frontal cortical atrophy and younger disease onset, and (3) patients without detectable cortical atrophy. These findings may help identify prognosis markers in Parkinson's disease. 15 May 2016
  • Movement Disorders Volume 31 Issue 5 Neuro-QoL health-related quality of life measurement system: Validation in Parkinson's diseaseConclusions: Neuro-QoL is valid for use in PD clinical research. Reliability for all but two measures is sufficient for group comparisons, with some evidence supporting responsiveness to change. Neuro-QoL possesses characteristics, such as brevity, flexibility in administration, and suitability, for cross-disease comparisons that may be advantageous to users in a variety of settings. 2 15 May 2016
  • Movement Disorders Volume 31 Issue 5 Loss of Nigral Hyperintensity on 3 Tesla MRI of Parkinsonism: Comparison With 123I-FP-CIT SPECTThe loss of nigral hyperintensity on susceptibility-weighted imaging suggested nigrostriatal dopaminergic degeneration in a large portion of patients with parkinsonism, which was indicated by 123I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane single photon emission computerized tomography. In consideration of false-negative and -positive cases, well-designed imaging protocols should be introduced to improve the performance of nigral hyperintensity imaging. 15 May 2016
  • Movement Disorders Volume 31 Issue 5 Alterations of putaminal shape in de novo Parkinson's diseaseConclusions: Shape analysis in de novo-PD patients suggested a progressive medial-to-lateral involvement of the putamina that paralleled an asymmetric-to-bilateral distribution of DA transporter depletion. 15 May 2016
  • npj Parkinson's Disease Analysis of four scales for global severity evaluation in Parkinson's diseaseThe present international, cross-sectional study was aimed at determining the agreement level among four global scales for PD (Hoehn and Yahr, HY; Clinical Global Impression of Severity, CGIS; Clinical Impression of Severity Index, CISI-PD; and Patient Global Impression of Severity, PGIS) and identifying which of them better correlates with itemized PD assessments. 05 May 2016
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