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Measurement and diagnosis research papers

Validating an objective video-based dyskinesia severity score in Parkinson's disease patientsThe authors have developed a semi-automatic video-based objective dyskinesia quantifying measure called the severity score (SVS) that was evaluated on 35 patient videos. They present a study to evaluate the utility of our severity score and compare its performance to clinical ratings of neurologists. 01 February 2013
Biomarkers of Parkinson's disease: current status and futureThis review summarizes major advances in biomarker discovery for diagnosis, differential diagnosis and progression of Parkinson's disease (PD), with emphasis on neuroimaging and biochemical markers. 01 February 2013
Naturally occurring α-synuclein autoantibody levels are lower in patients with Parkinson diseaseUsing a well-validated assay, authors detected reduced α-Syn-nAbs levels in patients with PD compared to patients with AD and HC. The assay did not achieve criteria for use as a diagnostic tool to reliably distinguish PD from HC. Further studies are needed to assess α-Syn-nAbs as a biomarker in PD. 08 January 2013
The Addenbrooke's Cognitive Examination for the differential diagnosis and longitudinal assessment of patients with parkinsonianAuthors propose the ACE-R, particularly the verbal fluency subscore, as a valuable contributor to the differential diagnosis of parkinsonian syndromes in the correct clinical context. The ACE-R may reflect disease progression in PD and CBD. 08 January 2013
The retina as a window to the brainfrom eye research to CNS disordersIn this Review, authors summarize data that support examination of the eye as a noninvasive approach to the diagnosis of select CNS diseases, and the use of the eye as a valuable model to study the CNS. Translation of eye research to CNS disease, and deciphering the role of immune cells in these two systems, could improve our understanding and, potentially, the treatment of neurodegenerative disorders. 01 January 2013
EFNS/MDS-ES recommendations for the diagnosis of Parkinson's diseaseConclusions: The diagnosis of PD is still largely based on the correct identification of its clinical features. Selected investigations (genetic, olfactory, and neuroimaging studies) have an ancillary role in confirming the diagnosis, and some of them could be possibly used in the near future to identify subjects in a pre-symptomatic phase of the disease. 01 January 2013
New horizons in the pathogenesis, assessment and management of movement disordersIn this review authors outline recent advances in our understanding of the movement disorders which geriatricians encounter in their clinical practice. 01 January 2013
Biomarkers for the diagnosis and management of Parkinson's diseaseRecent advances in diagnostic methods, encompassing imaging techniques, genetic testing and measurement of biological markers may permit earlier diagnosis, and thus potentially improved management of PD. 01 January 2013
Existing and emerging mitochondrial-targeting therapies for altering Parkinson's disease severity and progressionBoth drug-related and gene-based therapeutic approaches are discussed, with evidence presented from both animal modelling studies as well as product assessments undergoing various phases of clinical trial progression. 01 January 2013
Should One Measure Balance or Gait to Best Predict Falls among People with Parkinson Disease?Conclusion. A single measure of gait velocity, even in a challenging condition, may not be as effective as the Mini-BESTest in identifying fallers among people with PD. 20 December 2012

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