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Research papers


Measurement and diagnosis research papers

  • DNA Lower plasma Apolipoprotein A1 levels are found in Parkinson's disease and associate with apolipoprotein A1 genotyperesults are compatible with a model whereby circulating ApoA1 levels may be useful in risk-stratifying subjects for the development of PD, with higher ApoA1 levels suggesting relative protection. Future studies evaluating modulation of ApoA1 as a novel therapeutic strategy in PD are warranted. 15 May 2015
  • Parkinsonism & Related Disorders Volume 21 Issue 4 Learning effects of the sensory organization test as a measure of postural control and balance in Parkinson's diseaseMultiple baseline measures are usually recommended for any task used as an outcome measure. Study findings suggest that in PD subjects who are considered fallers that by the fourth session any improvement may be due to a learning effect. 14 May 2015
  • Parkinsonism & Related Disorders Volume 21 Issue 4 Abnormal thermography in Parkinson's diseaseConclusions PD patients reveal abnormal skin thermal responses in thermography with cold stress test, suggesting cutaneous autonomic dysfunction. This simple technique may be useful to evaluate autonomic dysfunction in PD. 13 May 2015
  • Parkinsonism & Related Disorders Volume 21 Issue 4 Olfactory function combined with morphology distinguishes Parkinson's diseaseConclusions: Although preliminary, these data obtained from a combined morphological and functional evaluation of OB or cardiovascular dysautonomia could be useful for further differential of PD and other PD-related disorders. 11 May 2015
  • Neurology Low muscle strength in late adolescence and Parkinson disease later in lifeConclusions: Maximal upper extremity voluntary muscle force was reduced in late adolescence in men diagnosed with PD 30 years later. The findings suggest the presence of subclinical motor deficits 3 decades before the clinical onset of PD. 05 May 2015
  • JNNP Volume 84 Chronological changes of 123I-MIBG myocardial scintigraphy and clinical features of Parkinson's diseaseConclusions Follow-up studies of MIBG divided the patients with PD into two major subgroups. A subgroup of patients with PD with normal or mildly low MIBG uptakes at the early stages of illness was characterised by female-dominant, young onset, slow progression in motor dysfunctions and preserved cognitive function. 02 May 2015
  • Parkinsonism & Related Disorders Volume 21 Issue 5 Biomarkers of cognitive decline in Parkinson's diseaseGiven that the underlying mechanisms of cognitive decline or dementia associated with PD remain unclear, there is currently no mechanism-based treatment available. Identification of biological markers, including neuroimaging, biofluids and common genetic variants, that account for the heterogeneity of PD related cognitive decline could provide important insights into the pathological processes that underlie cognitive impairment in PD. 01 May 2015
  • Movement Disorders Volume 30 Issue 4 Diffusion tensor imaging of the nigrostriatal fibers in Parkinson's diseaseThe objectives were to 1) develop a diffusion tensor tractography protocol for reliably tracking the nigrostriatal fibers on multicenter data; 2) test whether the integrities measured by diffusion tensor imaging of the nigrostriatal fibers are abnormal in PD; and 3) test whether abnormal integrities of the nigrostriatal fibers in PD patients are associated with the severity of motor disability and putaminal dopamine binding ratios. 29 April 2015
  • Movement Disorders Volume 30 Issue 5 International validation of a behavioral scale in Parkinson's disease without dementiaThe Ardouin Scale of Behavior in Parkinson's Disease is a new instrument specifically designed for assessing mood and behavior with a view to quantifying changes related to Parkinson's disease, to dopaminergic medication, and to non-motor fluctuations. This study was aimed at analyzing the psychometric attributes of this scale in patients with Parkinson's disease without dementia. 15 April 2015
  • Movement Disorders Volume 30 Issue 4 A population-based study on combined markers for early Parkinson's diseaseWhen combining SN+ and hyposmia, PPV increased to 17.6%, with a sensitivity of 51% and a specificity of 98%. Both SN+ and hyposmia offer good enrichment towards PD and ppPD, are stable against other diseases, and the combination of markers highly increases specificity. However, if the combination of SN+ and hyposmia were used as criterion for PD diagnosis, almost half of clinically definite PD and more than 90% of ppPD would have been missed. 15 April 2015
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