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Measurement and diagnosis research papers

  • Parkinsonism & Related Disorders Volume 21 Issue 12 Comparing results from long and short form versions of the parkinson's disease questionnaire in a longitudinal studyConclusions: The PDQ-8 closely replicates results gained from the PDQ-39 when calculating single indices. In instances where a single summary score of the impact of PD on self-reported quality of life is needed, it is likely the PDQ-8 will provide reliable and accurate information. 01 November 2015
  • Parkinsonism & Related Disorders Volume 21 Issue 12 Cognitive disorders in Parkinson's disease: confirmation of a spectrum of severityThis study's objective was to confirm prospectively a previous exploratory cluster analysis based on retrospective data that identified five cognitive phenotypes in PD. 01 November 2015
  • npj Parkinson's Disease Classification of symptom-side predominance in idiopathic Parkinson's diseaseTo scrutinize the predictive value of this consequential clinical phenomenon as a neuromarker supporting a personalized therapeutic approach, authors modeled symptom-side predominance at disease onset based on brain morphology assessed with magnetic resonance (MR) images by utilizing machine learning classification. 29 October 2015
  • xxx Blood transcriptomics of drug-naïve sporadic Parkinson's disease patientsStudy data support the use of blood transcriptomics to study neurodegenerative diseases. It identifies changes in crucial components of chromatin remodeling and methylation machineries as early events in sporadic PD suggesting epigenetics as target for therapeutic intervention. 28 October 2015
  • Movement Disorders Vol 30 Iss 12 MDS research criteria for prodromal Parkinson's diseaseThis diagnostic information combines estimates of background risk (from environmental risk factors and genetic findings) and results of diagnostic marker testing. In order to be included, diagnostic markers had to have prospective evidence documenting ability to predict clinical PD. They include motor and nonmotor clinical symptoms, clinical signs, and ancillary diagnostic tests. 16 October 2015
  • Movement Disorders Vol 30 Iss 12 King's Parkinson's disease pain scale, the first scale for pain in PD: An international validationCorrelation coefficients of the King's PD Pain Scale domains and total score with other pain measures were high. Correlation with the Scale for Outcomes in PD-Motor, Non-Motor Symptoms Scale total score, and quality of life measures was high. The King's PD Pain Scale seems to be a reliable and valid scale for grade rating of various types of pain in PD. 15 October 2015
  • Neurology Is normosmic Parkinson disease a unique clinical phenotype?These results suggest that normosmic PD is a unique clinical phenotype with a more benign course, compared to hyposmic PD. Either less pathologic involvement in the olfactory system or a greater potential for olfactory neurogenesis in normosmic PD may contribute to this benign process compared to hyposmic PD. 13 October 2015
  • Movement Disorders Volume 30 Issue 8 The NINDS Parkinson's disease biomarkers programConclusions: By making samples and data widely available, using stringent operating procedures based on existing standards, hypothesis testing for biomarker discovery, and providing a resource that complements existing programs, the Parkinson's Disease Biomarker Program will accelerate the pace of PD biomarker research. 07 October 2015
  • Parkinsonism & Related Disorders Volume 21 Issue 10 Optical coherence tomography as a tool to evaluate retinal changes in Parkinson's diseaseAuthors did not find any significant abnormality in the RNFL thickness in patients with PD. Decreased CMT in patients with PD and a significant negative correlation of RNFL thickness and CMT with severity of PD suggests a remote possibility of dopaminergic depletion in the retina. However long term studies are warranted to validate our findings. 01 October 2015
  • Parkinsonism & Related Disorders Volume 21 Issue 10 Elevated salivary protein in Parkinson's disease and salivary DJ-1 as a potential marker of disease severityThis study suggests that the saliva of patients with PD is different in composition to that of healthy age-matched controls, supporting the notion that saliva may be a good candidate for biomarker discovery in PD. The specific differences suggest that major salivary glands and gingival crevice fluid may both be sources of additional DJ-1 and protein in patient saliva. 01 October 2015
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