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Personality traits in patients with Parkinson's disease: assessment and clinical implicationsThe study concluded that the definition of a pre-motor phase of PD, based on non-motor symptoms, should search for the presence of concomitant affective disorders and for a positive psychiatric history for affective disorders rather than for a typical personality profile or personality changes. 01 June 2012
A molecular signature in blood identifies early Parkinson's diseaseThe findings provide evidence on the ability of a five-gene panel to diagnose early/mild PD, with a possible diagnostic value for detection of asymptomatic PD before overt expression of the disorder. 31 May 2012
Premotor biomarkers for Parkinson's disease - a promising direction of researchThe current review highlights recent advances and underscores areas of potential advancement. 31 May 2012
Dopamine Induced Neurodegeneration in a PINK1 Model of Parkinson's DiseaseThese data demonstrate the mechanism of dopamine toxicity in PINK1 deficient neurons, and suggest potential therapeutic strategies for neuroprotection in Parkinson's disease. 25 May 2012
PINK1 activated by mitochondrial membrane potential depolarization & stimulates Parkin E3 ligase activity by phosphorylating ...Study findings indicate that monitoring phosphorylation of Parkin at Ser65 and/or PINK1 at Thr257 represent the first biomarkers for examining activity of the PINK1-Parkin signalling pathway in vivo. Our findings also suggest that small molecule activators of Parkin that mimic the effect of PINK1 phosphorylation may confer therapeutic benefit for PD 23 May 2012
The association between Mediterranean diet adherence and Parkinson's diseaseHigher Mediterranean-type diet adherence was associated with reduced odds for PD after adjustment for all covariates (OR, 0.86; 95% CI, 0.770.97; P = .010). Lower Mediterranean-type diet score was associated with earlier PD age at onset (β = 1.09; P = .006). 15 May 2012
Alpha-synuclein in colonic submucosa in early untreated Parkinson's diseaseThis study suggests a pattern of α-synuclein staining in Parkinson's disease that was distinct from healthy subjects and those with inflammatory bowel disease. The absence of this pattern in subjects with inflammatory bowel disease suggests it is not a sequel of inflammation or oxidative stress. 15 May 2012
Sustained translational repression by eIF2α-P mediates prion neurodegenerationGiven the prevalence of protein misfolding and activation of the unfolded protein response in several neurodegenerative diseases, these results suggest that manipulation of common pathways such as translational control, rather than disease-specific approaches, may lead to new therapies preventing synaptic failure and neuronal loss across the spectrum of these disorders. 06 May 2012
Viral-toxin interactions and Parkinson's disease: poly(I:C) priming enhanced the neurodegenerative effects of paraquatThese findings suggest that viral agents can sensitize microglial-dependent inflammatory responses, thereby rendering nigral DA neurons vulnerable to further environmental toxin exposure. 04 May 2012
Physiological Phenotype and Vulnerability in Parkinson's DiseaseBecause much of the mitochondrial burden created by this at-risk phenotype is created by Ca2+ entry through L-type voltage-dependent channels for which there are antagonists approved for human use, a neuroprotective strategy to reduce this burden is feasible. 02 May 2012

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