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Mechanisms research papers

Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegenerationIn the present study, the authors sought to determine several other common dietary phenolics, namely, tea catechins [(+)-catechin and ()-epicatechin] and a representative flavonoid (quercetin), for their ability to modulate L-DOPA methylation and to protect against oxidative hippocampal injury. 01 February 2013
Parkinson's disease, insulin resistance and novel agents of neuroprotectionThe authors' aim is to highlight this converging evidence and stimulate further hypothesis-testing studies specifically with reference to the potential development of novel neuroprotective agents in Parkinson's disease. 01 February 2013
Cumulative exposure to lead and cognition in persons with Parkinson's diseaseThese data provide evidence suggesting that cumulative exposure to lead may result in worsened cognition among persons with PD. 01 February 2013
Parkinson's disease: From pathology to molecular disease mechanismsThere have been major advances in the understanding of mechanisms that contribute to nigral dopaminergic cell death, including mitochondrial dysfunction, oxidative stress, altered protein handling and inflammation. However, it is not known if the same processes are responsible for neuronal loss in non-dopaminergic brain regions. 01 February 2013
The genetics of Parkinson's disease: Progress and therapeutic implicationsMuch of the investigation into the biology underlying PD has used these findings to define a pathway, or pathways, to pathogenesis by trying to fit disparate genetic defects onto the same network. This work has had some success, particularly in the context of monogenic disease, and is beginning to provide clues about potential therapeutic targets. 31 January 2013
Curcumin and neurodegenerative diseasesHere, authors review the evidence from several animal models that curcumin improves healthspan by preventing or delaying the onset of various neurodegenerative diseases. 31 January 2013
Decreased iron levels in the temporal cortex in postmortem human brains with Parkinson diseaseConclusions: Iron deprivation and iron-related protein dysregulation suggest that a different iron regulatory mechanism may exist, and that iron redistribution may occur between the temporal cortex and the substantia nigra of patients with PD. 29 January 2013
Mitochondrial quality, dynamics and functional capacity in Parkinson's disease cybrid cell lines selected for Lewy body expressiConclusions: Expression of mitochondrial DNA derived from PD patients in cybrid cell lines induced the spontaneous formation of CLB. The creation of three sub-cloned cybrid lines from cells expressing CLB resulted in differential phenotypic changes in mitochondrial and cellular function. 26 January 2013
Delayed emergence of parkinsonian disorder or dementia in 81% of older males initially diagnosed with idiopathic REM sleep disorConclusion: The vast majority of men 50years old initially diagnosed with iRBD in this study eventually developed a parkinsonian disorder/dementia, often after a prolonged interval from onset of iRBD, with the mean interval being 14years while the range extended to 29years. Also, the specificity of iRBD converting to parkinsonism/dementia is striking. 24 January 2013
Methamphetamine and Parkinson's DiseaseConsistent with these similarities, recent epidemiological studies have shown that methamphetamine users are almost twice as likely as non-users to develop PD, despite the fact that methamphetamine abuse and PD have distinct symptomatic profiles. 15 January 2013

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