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Mechanisms research papers

  • Neuron Alpha-synuclein and tau: teammates in neurodegeneration?Moreover, tau and alpha-synuclein appear to promote the fibrillization and solubility of each other in vitro and in vivo. This suggests that interactions between tau and alpha-synuclein form a deleterious feed-forward loop essential for the development and spreading of neurodegeneration. 29 October 2014
  • DNA Mucuna pruriens mRescues Motor, Olfactory, Mitochondrial & Synaptic Impairment in PINK1B9 Drosophila melanogaster Genetic ModelOverall, this study strengthens the relevance of using PINK1B9 Dm as a translational model to study the properties of Mucuna pruriens for PD treatment. 23 October 2014
  • Neuron Upregulation of GPR109A in Parkinson's DiseaseThe findings of associations among the GPR109A receptor, niacin levels and night-sleep function in individuals with PD are novel. Further studies are needed to understand the pathophysiological mechanisms of action of niacin, GPR109A expression and their associations with night-sleep function. 17 October 2014
  • Brain activity Pallidal gap junctions-triggers of synchrony in Parkinson's disease?In this study, confocal imaging was used to detect connexin-36, the major neural gap junction protein, in postmortem tissues of PD patients and control subjects in the putamen, subthalamic nucleus (STN), and external and internal globus pallidus (GPe and GPi, respectively). 15 October 2014
  • Neuron Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutationsHere authors find that LRRK2 containing pathogenic Roc-COR domain mutations (R1441C, Y1699C) preferentially associates with deacetylated microtubules, and inhibits axonal transport in primary neurons and in Drosophila, causing locomotor deficits in vivo. 15 October 2014
  • Brain Parkinson disease and smoking revisitedAuthors propose that ease of smoking cessation is an aspect of premanifest PD similar to olfactory dysfunction, REM sleep disorders, or constipation and suggests that the apparent neuroprotective effect of smoking observed in epidemiologic studies is due to reverse causation. 14 October 2014
  • Brain skeleton RNA metabolism in the pathogenesis of Parkinsons diseaseIt is anticipated that continued studies on the role of RNA metabolism in Parkinsons disease will offer unifying mechanisms for understanding the cause of neuronal dysfunction and degeneration and facilitate the development of novel and rational strategies for treating this debilitating disease. 10 October 2014
  • Blood cells The role of iron in brain ageing and neurodegenerative disordersDuring ageing, different iron complexes accumulate in brain regions associated with motor and cognitive impairment. In various neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, changes in iron homoeostasis result in altered cellular iron distribution and accumulation. 01 October 2014
  • Brain A GCase Chaperone Improves Motor Function in a Mouse Model of SynucleinopathyThese data support the further investigation of pharmacological chaperones that target GCase as a therapeutic approach for sporadic PD and other synucleinopathies, even in the absence of glucocerebrosidase mutations. 01 October 2014
  • Brain Midlife migraine and late-life parkinsonismThese findings suggest there may be a common vulnerability to, or consequences of, migraine and multiple indicators of parkinsonism. Additional genetic and longitudinal observational studies are needed to identify candidate pathways that may account for the comorbid constellation of symptoms. 30 September 2014
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