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Mechanisms research papers
Isogenic Human iPSC Parkinson's Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription
Study data provide mechanistic insight into gene-environmental interaction (GxE) in the pathogenesis of PD. Furthermore, using small-molecule high-throughput screening, we identify the MEF2C-PGC1α pathway as a therapeutic target to combat PD.
27 November 2013
Oxidative Stress and Regulation of Pink1 in Zebrafish (Danio rerio)
The pink1 gene is a sensitive marker of oxidative stress in zebrafish, and LGR effectively normalizes the consequences of mild oxidative stress, suggesting that the neuroprotective effects of pink1 and LGR may be significant and useful in drug development.
26 November 2013
The Role of Innate and Adaptive Immunity in Parkinson's Disease
Given the implications of immune system involvement on disease progression, auithors conclude by reviewing the evidence supporting the potential efficacy of immunomodulatory therapies in PD prevention or treatment. There is a clear need for additional research to clarify the role of immunity and inflammation in this chronic, neurodegenerative disease.
25 November 2013
Microglial TNF-α mediates enhancement of dopaminergic degeneration by brain angiotensin
The present results show that microglial TNF-α plays a major role in angiotensin-induced dopaminergic cell death and that the microglial release of TNF-α is mediated by activation of angiotensin type-1 receptors, NADPH-oxidase, Rho-kinase and NFK-β.
23 November 2013
Yeast Reveal a Druggable Rsp5/Nedd4 Network that Ameliorates αSynuclein Toxicity in Neurons
Using unbiased phenotypic screens as an alternative to target-based approaches, authors discovered an N-aryl benzimidazole (NAB) that strongly and selectively protected diverse cell-types from α-syn toxicity.
22 November 2013
Low uric acid levels in patients with Parkinson's disease: evidence from meta-analysis
Conclusions: It was found that patients with PD had lower serum levels of uric acid than healthy controls and this association was more significant in men than in women. More efforts are encouraged to explore the prognostic and therapeutic implications for PD of the present findings.
18 November 2013
Fungal-derived semiochemical 1-octen-3-ol disrupts dopamine packaging and causes neurodegeneration
In this report, authors demonstrate via genetic, biochemical, and immunological studies that the common volatile fungal semiochemical 1-octen-3-ol reduces dopamine levels and causes dopamine neuron degeneration in Drosophila melanogaster.
11 November 2013
How Parkinsonian Toxins Dysregulate the Autophagy Machinery
Here, authors highlight the molecular mechanisms by which different PD toxins dysregulate autophagy/mitophagy and how alterations of these pathways play beneficial or detrimental roles in dopamine neurons. The convergent and divergent effects of PD toxins on mitochondrial function and autophagy/mitophagy are also discussed in this review.
08 November 2013
Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson's disease
Animal models could be ideal for interrogating the potential role of the intestines in the pathogenesis of PD; however, few current animal models of PD encompass these nonmotor features. Authors sought to establish a progressive model of PD that includes the gastrointestinal (GI) dysfunction present in human patients.
04 November 2013
Δ9tetrahydrocannabinol is protective through PPARγ dependent mitochondrial biogenesis in a cell culture model of Parkinson's
Even though Δ9THC and pioglitazone are both protective against MPP+ only Δ9THC induces PPARγ dependent mitochondrial biogenesis, a mechanism that may be beneficial for the treatment of PD.
01 November 2013
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