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Resting state functional connectivity of the striatum in Parkinson's diseaseTo address the question of which brain structures are functionally most affected by Parkinson's disease, the authors performed a resting-state functional magnetic resonance imaging study focused on striatal functional connectivity. 01 December 2012
Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in miceThese results strongly suggest that pesticides can initiate the progression of PD pathology and that this progression is based on the transneuronal and retrograde axonal transport of alpha-synuclein. 30 November 2012
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2Analysis of human brain tissue showed nuclear-envelope impairment in clinically diagnosed Parkinson's disease patients. Together, these results identify the nucleus as a previously unknown cellular organelle in Parkinson's disease pathology and may help to open new avenues for Parkinson's disease diagnoses as well as for the potential development of therapeutics targeting this fundamental cell structure. 22 November 2012
Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeatHere authors identify a nuclear-enriched lncRNA antisense to mouse ubiquitin carboxy-terminal hydrolase L1 (Uchl1), a gene involved in brain function and neurodegenerative diseases. 15 November 2012
Thalamic noradrenaline in Parkinson's disease: Deficits suggest role in motor and non-motor symptomsThe marked noradrenergic deafferentiation of the thalamus discloses a strategically located noradrenergic component in the overall pathophysiology of PD, suggesting a role in the complex mechanisms involved with the genesis of the motor and non-motor symptoms. 15 November 2012
Development and Characterization of a New Parkinson's Disease Model Resulting from Impaired AutophagyUsing transgenic mice expressing Cre recombinase under the control of either the dopamine transporter or the engrailed-1 promoters, authors generated mice with the conditional deletion of Atg7 in the dopamine neurons of the substantia nigra pars compacta, other regions of the midbrain, and also the hindbrain. 14 November 2012
Traumatic brain injury, paraquat exposure, and their relationship to Parkinson diseaseConclusions: While TBI and paraquat exposure each increase the risk of PD moderately, exposure to both factors almost tripled PD risk. These environmental factors seem to act together to increase PD risk in a more than additive manner. 13 November 2012
Head injury and Parkinson's disease: A population-based studyAuthors examined the relation between previous hospitalization for head injury and PD using a population-based nested case-control design based on the Swedish National Patient Register from 2001 until 2007, including 18,648 PD cases and 93,240 controls, randomly selected from the general population. 09 November 2012
Cerebral causes and consequences of parkinsonian resting tremor: a tale of two circuits?The purpose of this review is to integrate these clinical and pathophysiological features of tremor in Parkinson's disease. Authors first describe clinical and pathological differences between tremor-dominant and non-tremor Parkinson's disease subtypes, and then summarize recent studies on the pathophysiology of tremor. 01 November 2012
Vasoactive Intestinal Peptide Enhances Striatal Plasticity and Prevents Dopaminergic Cell Loss in Parkinsonian RatsIn conclusion, VIP might display synaptogenetic activity by enhancing the spine density in the striatum of the parkinsonian rats. 01 November 2012

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