Skip to content
Search our Site
Search our site
Search our site
About the EPDA
Political affairs and policy
Resources and publications
All research papers
Search research papers
Mechanisms research papers
Olfactory dysfunction in sporadic Parkinson's Disease and LRRK2 carriers
Hyposmia was pronounced already at time of diagnosis in the sPD cases but was not present in healthy LRRK2 mutation carriers and less pronounced in LRRK2 PD compared with sporadic cases. Smell testing may be a preclinical marker in sporadic PD but does not seem applicable in LRRK2 cases.
13 August 2013
The Parkinson's diseaselinked proteins Fbxo7 and Parkin interact to mediate mitophagy
Here authors show that Fbxo7 participates in mitochondrial maintenance through direct interaction with PINK1 and Parkin and acts in Parkin-mediated mitophagy.
11 August 2013
Diapocynin prevents early Parkinson's disease symptoms in the leucine-rich repeat kinase 2 (LRRK2R1441G) transgenic mouse
Decreased performance on the pole test and Rotor-Rod in the LRRK2R1441G mice was prevented with diapocynin treatment. No loss in open field movement or rearing was found. As expected, tyrosine hydroxylase staining was similar in both the substantia nigra and striatum in all treatment groups. Together these data demonstrate that diapocynin is a viable agent for protection of neurobehavioral function.
08 August 2013
Cortical thinning is associated with disease stages and dementia in Parkinson's disease
Authors conclude that measuring cortical thickness can be useful in assessing disease stage and cognitive impairment in patients with PD. In addition, cortical thickness may be useful in identifying dementia in PD.
01 August 2013
Structure of the human Parkin ligase domain in an autoinhibited state
Authors here report the crystal structure of human Parkin spanning the Unique Parkin domain (UPD, also annotated as RING0) and RBR domains, revealing a tightly packed structure with unanticipated domain interfaces.
31 July 2013
Discontinuation of statin therapy associates with Parkinson disease
Conclusions: Continuation of lipophilic statin therapy was associated with a decreased incidence of PD as compared to discontinuation in statin users, especially in subgroups of women and elderly.
30 July 2013
Parkinson's Disease and the Sunshine Vitamin
Herein authors evaluated existing results, and outline several biological mechanisms by which the hypovitaminosis D-PD relationship may occur. They performed a meta-analysis, using data obtained from a search of PubMed from July 2002 to July 2012, for studies reporting serum vitamin D levels in PD and control patients.
23 July 2013
Castration Induces Parkinson Disease Pathologies in Young Male Mice via Inducible Nitric-oxide Synthase
Together, these results suggest that castration induces nigrostriatal pathologies via iNOS-mediated decrease in GDNF. These results are important because castrated young male mice may be used as a simple, toxin-free, and nontransgenic animal model to study PD-related nigrostriatal pathologies, paving the way for easy drug screening against PD.
19 July 2013
Parkinson's disease and pesticide exposure a new assessment Read More: http://informahealthcare.com/doi/abs/10.3109/10408444
The results of the meta-analysis reported in this study suggest the existence of a statistically positive association between PD and pesticide exposure. The majority of the studies that were pooled in the meta-analysis were case-control design with very few cohort studies and most with poor exposure characterization thus, any further case-control studies using similar methodologies are unlikely to have a significant impact or understanding on the currently-reported association between pesticide exposure and
12 July 2013
Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons
Many neurodegenerative diseases are characterized by the accumulation of insoluble protein aggregates, including neurofibrillary tangles comprised of tau in Alzheimer's disease and Lewy bodies composed of α-synuclein in Parkinson's disease. Moreover, different pathological proteins frequently codeposit in disease brains. To test whether aggregated α-synuclein can directly cross-seed tau fibrillization, authors administered preformed α-synuclein fibrils assembled from recombinant protein to primary neurons a
03 July 2013
Back to Top
Add page to PDF basket
Copyright © 2013 EPDA. All Rights Reserved.
Privacy and cookies