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Mechanisms research papers

  • DNA Formulations of hormone therapy and risk of Parkinson's diseaseThe findings from this study suggest an increase in PD risk associated with esterified estrogen use combined with progestin, and no risk associated with conjugated estrogen with progestin. These findings could have important implications for choice of HT in clinical practice. 15 November 2014
  • Neuron DNA methylation of the MAPT gene in Parkinson's disease cohorts and modulation by vitamin E In VitroThe significant effects of sex, diplotype, and brain region suggest that hypermethylation of the MAPT gene is neuroprotective by reducing MAPT expression. The effect of vitamin E on MAPT represents a possible gene-environment interaction. 15 November 2014
  • Test tubes Dietary fat intake and risk for Parkinson's diseaseThe study suggests that fat intake in general is not related to the risk for PD. The weak positive association between intake of n-6 PUFA and PD risk needs further investigation. 15 November 2014
  • xxx The role of the LRRK2 gene in ParkinsonismIn this review, authors discuss the pathology and clinical features which show diversity and variability of LRRK2-associated PD. In addition, they do a thorough literature review and provide theoretical data for gene counseling. Further, we present the evidence linking LRRK2 to various possible pathogenic mechanism of PD such as α-synuclein, tau, inflammatory response, oxidative stress, mitochondrial dysfunction, synaptic dysfunction as well as autophagy-lysosomal system. 12 November 2014
  • Brain Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain SynthesisStudy data reveal a feedforward mechanism that explains how PINK1 phosphorylation of both PARKIN and poly-UB chains synthesized by PARKIN drives a program of PARKIN recruitment and mitochondrial ubiquitylation in response to mitochondrial damage. 06 November 2014
  • Neuron Neurotransmitter receptor density changes in Pitx3ak mice A model relevant to Parkinson's diseaseAuthors demonstrated striking differential changes of neurotransmitter receptor densities for numerous receptor types and brain regions, respectively. Most prominent, a strong up-regulation of GABA receptors and associated benzodiazepine binding sites in different brain regions and concomitant down-regulations of striatal nicotinic acetylcholine and serotonergic receptor densities were found. 05 November 2014
  • Neuron Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivoSpecifically, authors show that inhibition of the mitochondrial fission GTPase dynamin-related protein-1 (Drp1) using gene-based and small-molecule approaches attenuates neurotoxicity and restores pre-existing striatal dopamine release deficits in these animal models. These results suggest Drp1 inhibition as a potential treatment for PD. 05 November 2014
  • Neuron The Future of Research in Parkinson DiseaseThere are many unanswered questions about Parkinson disease (PD), but as a result of advances in genetics, proteomics, metabolomics, epigenetics, imaging, and other novel techniques, remarkable progress is being made. In this Viewpoint, authors will highlight aspects of future research aimed at addressing the following critical questions. 01 November 2014
  • Brain synapse Lifetime exposure to Estrogens and Parkinson's disease in California teachersConclusions: These results provide some support for the hypothesis that lifelong high estrogen is protective in PD, suggesting that the level and persistence of exposure over the long term may be important in PD risk reduction. 01 November 2014
  • Brain Glucocerebrosidase mutations in primary parkinsonismConclusion: GBA dysfunction is relevant for synucleinopathies, such as PD and DLB, except for MSA, in which pathology involves oligodendrocytes, and the tauopathies PSP and CBD. The risk of developing DLB is three-fold higher than PD, suggesting a more aggressive phenotype. 01 November 2014
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