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Medication research papers

  • Clasped hands Prevalence and features of peripheral neuropathy in Parkinson's disease patients under different therapeutic regimensOur findings support the relationship between levodopa and PN and confirm that an imbalance in VB12/hcy may be a key pathogenic factor. Authors suggest two different, possibly overlapping mechanisms of PN in patients on CDLII: axonal degeneration due to vitamin deficiency and inflammatory damage. Whether inflammatory damage is triggered by vitamin deficiency and/or by modifications in the intestinal micro-environment should be further explored. 01 January 2014
  • Brain Pathogenesis-Targeted, Disease-Modifying Therapies in Parkinson DiseaseIn this article, authors will review previous, ongoing, and potential future trials designed to alter the progressive course of the disease from the perspective of the targeted underlying pathogenic mechanisms. 01 January 2014
  • Brain Dopaminergic modulation of motor coordinaton in Parkinson's diseaseConclusions: The study demonstrates dopaminergic modulation of motor coordination in PD and supports that the analysis of different components of multi-finger synergies offers a set of indices sensitive to the effects of dopamine replacement therapy in early-stage PD. The results suggest an important role of the basal ganglia in synergy formation and in feed-forward synergy adjustments. 01 January 2014
  • Brain activity Levodopa infusion improves impulsivity and dopamine dysregulation syndrome in Parkinson's diseaseConclusions: The authors' experience suggests that l-dopa infusion has a positive effect on both motor complications and behavioral disorders. This treatment approach deserves further controlled studies. 15 December 2013
  • Pills medication tablets Effects of rasagiline on olfactory function in patients with Parkinson's diseaseResults: When comparing olfactory score differences between baseline and after 120 days between the 2 groups, the level of significance was not reached. 15 December 2013
  • Brain Dopamine overdose hypothesis: Evidence and clinical implicationsIn this review, authors consider the evidence that has accumulated in the areas of reversal learning, motor sequence learning, and other cognitive tasks. The purported inverted-U shaped relationship between dopamine levels and performance is complex and includes many contributory factors. 15 December 2013
  • Quality of Life Friends Couple walking in woods Subcutaneous apomorphine and non-motor symptoms in Parkinson's diseaseResults of this review suggest that although data on the effect of apomorphine on NMS in PD patients are limited there is a strong suggestion of a beneficial effect that warrants further investigation in double-blind studies. 01 December 2013
  • Man with stick Rasagiline treatment effects on parkinsonian tremorSignificant improvement was evident as early as 10 weeks from treatment initiation. Tremor symptoms also improved in a subset of patients with severe tremor when rasagiline was added to their existing PD treatment regimen. These data suggest that rasagiline used as monotherapy and as adjunctive therapy is effective for reducing tremor severity in patients with PD. 01 December 2013
  • Neuron Protective Effects of Zonisamide Against Rotenone-Induced NeurotoxicityOn the whole, these findings suggest that ZNS preserves mitochondrial functions and counteracts apoptotic signalling mechanisms mainly by an antioxidant action. Thus, ZNS might have beneficial effect against neuronal cell degeneration in different experimental models involving mitochondrial dysfunction. 01 December 2013
  • xxx Motor fluctuations and Helicobacter pylori in Parkinson's diseaseThe objectives of this study were to investigate whether HP infection may affect the clinical response to levodopa as well as levodopa dose requirement in patients with Parkinson's disease (PD) as well as to investigate whether HP infection may affect plasma levels of vitamin B12, folic acid, and homocysteine. 01 December 2013
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