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Research papers


Quality of life (QoL) research papers

  • Quality of Life Friends Couple walking in woods The development and validation of a quality of life measure for the carers of people with Parkinson's disease (the PDQ-Carer)Survey results suggest a 29-item questionnaire tapping four dimensions of quality of life (Social and Personal Activities, Anxiety and Depression, Self care, and Strain). Internal consistency reliability was found to be high for all domains. Data completeness was high. Construct validity (assessed by correlations with a generic measure of quality of life) confirmed prior hypotheses. 01 May 2012
  • Headache Pain Prevalence of pain in Parkinson's: A systematic review using the modified QUADAS toolSurprisingly, only 52.4% of PD patients with pain used analgesics, most often nonopioids. PD patients seem to be predisposed to develop pain and physicians should be aware of pain as a common feature of PD. 15 April 2012
  • Headache Pain Pain in Parkinson's diseaseIncreased understanding of basal ganglia pathways has provided further insights into the pathogenesis of pain in PD, but the exact mechanism of pain processing and modulation remains unclear. 15 April 2012
  • Clasped hands Quality of life and burden in caregivers for patients with Parkinson's disease: concepts, assessment and related factorsStudies have identified factors related to caregivers' global QoL and health-related QoL, causing caregivers distress and affecting their QoL. These factors are related to patients' and caregivers' characteristics and may be classified as sociodemographic, psychological and disease related. Caregiver's burden refers to the multiplicity of difficulties ensuing as a consequence of caring, including, for example, health problems, modification of habits, economic loss and QoL deterioration. 01 April 2012
  • Quality of Life Friends Couple walking in woods Nonmotor versus motor symptoms: How much do they matter to health status in Parkinson's disease?Findings provide a ranking order of clinical variables for their relative impact on health status in Parkinson's disease and show that depression has more than twice the impact of motor signs on health status. Anxiety and other nonmotor symptoms are also important separate determinants of poor health status in Parkinson's disease. 15 February 2012
  • Brain scan Impact of apathy on health-related quality of life in recently diagnosed Parkinson's disease: The ANIMO studyApathetic PD patients showed EuroQol-5D index scores significantly lower than those without apathy (0.64 vs 0.83). In an adjusted model, apathetic PD patients were 2.49 times more likely to have lower HRQOL than nonapathetic patients (odds ratio, 2.49; 95% confidence interval, 1.494.15, P < 0.01). 15 February 2012
  • Brain activity Neurostimulation for Parkinson's Disease with Early Motor ComplicationsResults: For the primary outcome of quality of life, the mean score for the neurostimulation group improved by 7.8 points, and that for the medical-therapy group worsened by 0.2 points (between-group difference in mean change from baseline to 2 years, 8.0 points; P=0.002). Neurostimulation was superior to medical therapy with respect to motor disability (P<0.001), activities of daily living (P<0.001), levodopa-induced motor complications (P<0.001), and time with good mobility and no dyskinesia (P=0.01). 14 February 2012
  • Brain activity A Second Honeymoon for Parkinson's Disease?Medical therapy for Parkinson's disease is most effective in treating the motor symptoms of resting tremor, bradykinesia, and rigidity. Levodopa remains the most effective current treatment for motor symptoms; . . . 14 February 2012
  • Man with stick Relationships between motor aspects of gait impairments and activity limitations in people with PD: A systematic reviewThe objective of this review is to investigate the relationships between gait impairments and activity limitations in people with idiopathic PD. Six electronic databases (MEDLINE ISI, CINAHL, Web of Science ISI, EMBASE, PsycINFO and Scopus) were systematically searched using relevant terms to source for English-language studies published between 1900 and January 2011. 01 February 2012
  • Quality of Life Friends Couple walking in woods Loss of ability to work and ability to live independently in Parkinson's diseaseHigher UPDRS dyskinesia score, UPDRS instability score, UPDRS total score, Hoehn and Yahr stage, and presence of intellectual impairment at baseline were all associated with increased risk of future loss of ability to work and loss of ability to live independently (P 0.0033). Five years after initial visit, for patients 70 years of age with a disease duration 4 years at initial visit, 88% were still able to work and 90% to live independently. 01 February 2012
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