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Surgery research papers

Deep brain stimulation in benign tremulous parkinsonismThese findings support the efficacy of DBS, with VIM and STN targets, in medically refractory BTP-related tremor. 12 August 2011
Direct generation of functional dopaminergic neurons from mouse and human fibroblastsHere authors identified a minimal set of three transcription factorsMash1 (also known as Ascl1), Nurr1 (also known as Nr4a2) and Lmx1athat are able to generate directly functional dopaminergic neurons from mouse and human fibroblasts without reverting to a progenitor cell stage. 11 August 2011
GPi-DBS may induce a hypokinetic gait disorder with freezing of gait in patients with dystoniaThe aim of this work was to determine the frequency and the nature of the GPi-DBSinduced phenomenon. 02 August 2011
A cost analysis of intraoperative microelectrode recording during subthalamic stimulation for Parkinson's diseaseThe cost burden of microelectrode recording to subthalamic nucleus deep brain stimulation requires the clinical efficacy of microelectrode recording to be proven in a prospective evidence-based manner in order to curtail the potential for excessive financial burden to the health care system. 14 July 2011
Shaping reversibility? Long-term deep brain stimulation in dystonia: effects on electrophysiology and clinical symptomsThis suggests that it might be possible to 'shape' deep brain stimulation of an individual patient to maximize beneficial neurophysiological patterns that have an impact on clinical status. 01 July 2011
Will New Cellular Models of Parkinson's Disease Advance Understanding of Disease and Therapy?A great hope relies on a new technique called 'nuclear reprogramming', to generate cellular models based on the ability to manipulate somatic cells and modify their epigenetic signature, thus producing embryonic stem cell-like cells. 01 July 2011
Future Therapies How Close is Tomorrow?In summary, we are a long way from achieving PD-modifying gene therapy, but symptomatic gene therapy may be a realistic option in the near future (Phase II trials are ongoing). Cell-based therapies have already been proved-in-principle, but many unanswered questions exist. 01 July 2011
Diagnosis and treatment of complications related to deep brain stimulation hardwareThe study aim is to provide a guide for clinicians and medical staff involved in the treatment of patients with deep brain stimulation for rapid recognition and efficient management of these complications. 28 June 2011
Cognitive outcome and reliable change indices two years following bilateral subthalamic nucleus deep brain stimulationThe number of STN-DBS patients who converted to dementia 2 years following surgery was not significantly different from the PD participants (32% versus 16%, respectively). Study results suggest that neuropsychological evaluations may identify possible mild cognitive changes following surgery. 01 June 2011
Lateral ventricle volume is poor predictor of post unilateral DBS motor change for Parkinson's diseaseVentricular volume was a poor predictor of acute motor change following DBS. Asymmetrical ventricles may not be a consistent imaging marker for PD motor dysfunction. 01 June 2011

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