Skip to content
Search our Site
Search our site
Search our site
My PD Journey
About the EPDA
Political affairs and policy
Resources and publications
All research papers
Search research papers
Surgery research papers
Subthalamic deep brain stimulation: clinical and neuropsychological outcomes in mild cognitive impaired parkinsonian patients
Study findings confirm the sustained long-lasting efficacy of STN-DBS on motor functions in both PD-MCI and normal cognition subjects. PD-MCI patients showed a more precocious cognitive impairment, as expected by natural history studies, but no case of dementia was observed early after surgery.
01 September 2014
The Rationale Driving the Evolution of Deep Brain Stimulation to Constant-Current Devices
There has been little reporting of the use of constant-current DBS devices in movement and neuropsychiatric disorders. However, as impedance varies considerably between patients and over time, it makes sense that all new devices will likely use constant current.
29 August 2014
Effects of deep brain stimulation of the subthalamic nucleus on freezing of gait in Parkinson's: a prospective controlled study
In contrast to continued BMT, STN-DBS reduced FOG occurrence and severity at 6 months postsurgery with largely sustained effects at 12 months follow-up. Longer follow-up periods are needed to test whether FOG improvements after STN-DBS persist with disease progression.
01 August 2014
Network modulation following sham surgery in Parkinson's disease
Patient responses to placebo and sham effects are a major obstacle to the development of therapies for brain disorders, including Parkinson's disease (PD). Here, we used functional brain imaging and network analysis to study the circuitry underlying placebo effects in PD subjects randomized to sham surgery as part of a double-blind gene therapy trial.
18 July 2014
Impulse control behaviours in patients with Parkinson's after subthalamic DBS: de novo cases and 3-year follow-up
Conclusions ICBs were abolished in patients 3 years after STN DBS and DAA dosages were lowered. New ICBs may occur after implant and are transient in most cases. Compulsive eating may be specifically related to STN stimulation.
10 July 2014
Subthalamic nucleus deep brain stimulation in early stage Parkinson's disease
This study demonstrates that subjects with early stage PD will enroll in and complete trials testing invasive therapies and provides preliminary evidence that DBS is well tolerated in early PD. The results of this trial provide the data necessary to design a large, phase III, double-blind, multicenter trial investigating the safety and efficacy of DBS in early PD.
01 July 2014
Long-Term Health of Dopaminergic Neuron Transplants in Parkinson's Disease Patients
To determine the long-term health and function of transplanted dopamine neurons in Parkinson's disease (PD) patients, the expression of dopamine transporters (DATs) and mitochondrial morphology were examined in human fetal midbrain cellular transplants.
26 June 2014
The effect of deep brain stimulation randomized by site on balance in Parkinson's disease
Clinical measures of balance function for both the STN and GPi sites showed that balance did not improve beyond the best medically treated state before surgery. Both clinical balance testing in the off/off state and self-reported balance confidence after surgery showed better performance in the GPi than the STN group.
15 June 2014
The safety and efficacy of thalamic deep brain stimulation in essential tremor: 10 years and beyond
Conclusions: Thalamic DBS is a safe and effective therapy in patients with essential tremor followed for up to 13 years.
01 May 2014
STN lesion improves cell survival and functional recovery following dopaminergic cell transplantation in parkinsonian rats
These data suggest that the STN/ZI partial lesion optimized the striatal environment, promoting an improvement in cell survival. Further studies are needed to see whether the synergy between STN modulation via deep brain stimulation and cell therapy might have clinical applications in the management of PD.
01 May 2014
Back to Top
Add page to PDF basket
Copyright © 2015 EPDA. All Rights Reserved.
Privacy and cookies