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Surgery research papers
Subthalamotomy-induced changes in dopamine receptors in parkinsonian monkeys
The improved motor response to l-DOPA after subthalamotomy in the parkinsonian monkeys investigated may be associated with an increased synthesis and expression of D1 receptors ipsilateral to STN lesion of the direct pathway.
01 November 2014
Predicting quality of life outcomes after subthalamic nucleus deep brain
The findings provide greater insight into the nonmotor features that contribute to the success of subthalamic nucleus DBS procedures from the patient's perspective and raise questions about the treatment focus and emphasis on symptom profiles in DBS candidacy evaluations.
28 October 2014
Autonomic symptoms in Parkinson's disease
Despite a growing interest in the problem of autonomic dysfunction in PD, few studies have focused on autonomic dysfunction in PD, the patient's perspective about autonomic symptoms, and the relative differences between DBS and Non-DBS participants with respect to autonomic disturbances.
23 October 2014
Changes in Vowel Articulation with Subthalamic Nucleus Deep Brain Stimulation in Dysarthric Speakers with Parkinson's Disease
Results suggest that STN DBS may improve articulation in dysarthric speakers with PD, in terms of range of movement. Optimization of the electrical parameters for each patient is important and may lead to improvement in speech fine motor control. However, the impact on overall speech intelligibility may still be small.
21 October 2014
Distinct phenotypes of speech and voice disorders in Parkinson's disease after subthalamic nucleus deep brain stimulation
Conclusions: Stuttering and breathy voice can be aggravated by STN-DBS, but are mainly due to aging or PD itself. Strained voice and spastic dysarthria are considered corticobulbar side effects.
03 October 2014
The Impact of STN Deep Brain Stimulation on Speech in Individuals with Parkinson's Disease: The Patient's Perspective
Conclusion: DBS therapy's contribution to speech disturbance is gaining more attention, and the speech symptoms ensuing from and/or being exacerbated by DBS are in the incipient stages of being investigated. Implications for DBS therapy on perceived quality of life are discussed.
01 October 2014
Stimulation of the pedunculopontine nucleus area in Parkinson's disease: effects on speech and intelligibility
Although limited in this group of patients, speech impairment following pedunculopontine nucleus area stimulation is a possible outcome that should be considered before undertaking such surgery. Deleterious effects could be dependent on electrode insertion in this brainstem structure, more than on current spread to nearby structures involved in speech control.
01 October 2014
Effects of deep brain stimulation on pain and other nonmotor symptoms in Parkinson disease
Conclusions: STN-DBS decreased pain after surgery, but had different effects in different types of PD-related pain. Motor and nonmotor symptom improvements after STN-DBS did not correlate with pain relief.
12 September 2014
Neuropsychological changes following DBS surgery for Parkinson's: comparisons of treatment at pallidal & subthalamic targets ver
Conclusions: In those with PD, the likelihood of significant decline in neuropsychological functioning increases with DBS, affecting a small minority of patients who also appear to respond less optimally to DBS by other indicators of QOL.
02 September 2014
Which target is best for patients with Parkinson's disease? A meta-analysis of pallidal and subthalamic stimulation
The effect of GPi DBS was similar to STN DBS except for depression, however, only three studies described depression as adverse events. We need additional randomised trials with direct comparison between targets based on unified scoring of adverse events.
01 September 2014
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