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Surgery research papers

Effects of deep brain stimulation amplitude on motor performance in Parkinson's diseaseConclusion: Individual differences in the DBS dose-response curves may provide opportunities to optimize clinical performance. Day-to-day variability in motor performance cautions against the use of a single UPDRS measurement in clinical selection of DBS settings. 11 December 2012
Long-term outcomes of surgical therapies for Parkinson's diseaseHere, authors analyze the long-term clinical outcomes of surgical PD patients with at least 5-year follow-up, focusing on the long-term motor symptoms that were initially responsive to surgery. 03 December 2012
Setting realistic expectations for DBS in dystoniaThe modern era of deep brain stimulation (DBS) began in 1987, after Alim Louis Benabid's report on the successful implantation of an electrical lead in the ventral intermediate thalamus to provide chronic stimulation for the suppression of medication-refractory tremor. 01 December 2012
Typical and atypical stem cells in the brain, vitamin C effect and neuropathologyIn this review, authors analyze stem cells in embryonic and adult brains, and illustrate the differentiation pathways that give origin to most brain cells. They also evaluate the emergent role of the well known anti-oxidant, vitamin C, in stem cell differentiation. 01 December 2012
Effect of Deep Brain Stimulation on Speech Performance in Parkinson's DiseaseThe aim of this paper is to review and evaluate reports in the literature on the effects of DBS on speech function in PD. 20 November 2012
Deep brain stimulation of the subthalamic nucleus in Parkinson's disease: Why so successful?The great success of STN DBS for the treatment of advanced PD is underlined by the growing number of patients treated. STN DBS also provided additional insight into the role of the STN, which is important not only in motor control but also in cognitive and emotional functions. 31 October 2012
Association of Deep Brain Stimulation Washout Effects With Parkinson Disease DurationWashout of STN DBS effects varies with Parkinson disease duration. Estimates of proper washout time based on one patient population may not apply to populations with different disease durations. 15 October 2012
Unilateral Extradural Motor Cortex Stimulation Is Safe and Improves Parkinson Disease at 1 YearConclusion: Extradural motor cortex stimulation is a safe procedure. After 12 months, the patients demonstrated a moderate improvement of motor symptoms (particularly axial symptoms) and quality of life. 15 October 2012
Transplanting Intact Donor Tissue Enhances Dopamine Cell Survival & Predictability of Motor Improvements in a Rat Model of PDWhen assessing the correlation between the number of dopamine cells in each transplant, and the improvement in rotation bias in experimental animals, it was shown that transplants of whole pieces of VM tissue offered greater predictability of graft function based on their dopamine cell content. 09 October 2012
Reprogramming of Pericyte-Derived Cells of the Adult Human Brain into Induced Neuronal CellsHere authors show that cells from the adult human cerebral cortex expressing pericyte hallmarks can be reprogrammed into neuronal cells by retrovirus-mediated coexpression of the transcription factors Sox2 and Mash1.results support the idea that human ESCs, if appropriately matured, can serve as a source for dopaminergic neurons without forming any tumors in a primate brain. 05 October 2012

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