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Surgery research papers
High frequency stimulation of STN results in behavioral recovery by increasing striatal dopamine release in 6-hydroxydopamine le
Study results showed that HFS-STN improved the motor symptoms of 6-OHDA lesioned rat model of PD via inducing a significant increase in the extracellular dopamine levels and directly evoked dopamine release in the striatum of normal and partially 6-OHDA lesioned rats.
15 April 2014
Resting state functional MRI in Parkinson's disease: the impact of deep brain stimulation on 'effective' connectivity
In this work, authors model the 'effective' connectivity underlying low frequency blood oxygen level-dependent fluctuations in the resting Parkinsonian motor networkdisclosing the distributed effects of deep brain stimulation on cortico-subcortical connections.
01 April 2014
Health Economics and Surgical Treatment for Parkinson's Disease in a World Perspective: Results from an International Survey
This study provides a previously unavailable picture of the surgical aspects of PD across the globe in relation to health economics and sociodemographic factors. Global educational and training programs are warranted to raise awareness of economically viable surgical options for PD that could be adopted by public health care systems in lower-income countries.
01 April 2014
Deep brain stimulation of the subthalamic nucleus improves pain in Parkinson's disease
Results: All pain scores were significantly improved 12 months after STN-DBS. This improvement was not correlated with motor improvement, depression scores or l-Dopa reduction.
31 March 2014
Gene therapy for Parkinson's disease: a step closer?
Parkinson's disease is the second most common neurodegenerative disorder. The annual cost in Europe was nearly €14 billion in 2010, 1 and the effect on quality of life for patients and their families is incalculable.
29 March 2014
Increased Precursor Cell Proliferation after Deep Brain Stimulation for Parkinson's Disease: A Human Study
Study data suggest that DBS is capable of increasing cellular plasticity in the brain, and we hypothesize that it may have more widespread effects beyond the electrode location. It is unclear whether these effects of DBS have any symptomatic or other beneficial influences on PD.
03 March 2014
Mood and behavioural effects of subthalamic stimulation in Parkinson's disease
In Parkinson's disease, the pathological STN neuronal activity leads to motor, cognitive, and emotional inhibition. Deafferentation of the STN by DBS can reverse such behavioural inhibition.
01 March 2014
Utilizing Fast Spin Echo MRI to Reduce Image Artifacts & Improve Implant/Tissue Interface Detection in Refractory PD with DBS
Authors wanted to identify which MRI sequence can detect DBS leads with smallest artifactual signal void, allowing better tissue/electrode edge conspicuity.
25 February 2014
Safety and tolerability of intracerebroventricular PDGF-BB in Parkinson's disease patients
CONCLUSION. At all doses tested, i.c.v. administration of rhPDGF-BB was well tolerated. Results support further clinical development of rhPDGF-BB for patients with PD.
17 February 2014
Subthalamic nucleus deep brain stimulation improves somatosensory function in Parkinson's disease
This study offers the first evidence that STN-DBS improves haptic precision, further indicating that somatosensory function is improved by STN-DBS. Authors conclude that DBS-related improvements are not explained by improvements in motor function alone, but rather by enhanced somatosensory processing.
15 February 2014
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