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Neurostimulation for Parkinson's Disease with Early Motor ComplicationsResults: For the primary outcome of quality of life, the mean score for the neurostimulation group improved by 7.8 points, and that for the medical-therapy group worsened by 0.2 points (between-group difference in mean change from baseline to 2 years, 8.0 points; P=0.002). Neurostimulation was superior to medical therapy with respect to motor disability (P<0.001), activities of daily living (P<0.001), levodopa-induced motor complications (P<0.001), and time with good mobility and no dyskinesia (P=0.01). 14 February 2012
A Second Honeymoon for Parkinson's Disease?Medical therapy for Parkinson's disease is most effective in treating the motor symptoms of resting tremor, bradykinesia, and rigidity. Levodopa remains the most effective current treatment for motor symptoms; . . . 14 February 2012
Subthalamic DBS with a constant-current device in Parkinson's disease: an open-label randomised controlled trialInterpretation: Constant-current DBS of the subthalamic nucleus produced significant improvements in good quality on time when compared with a control group without stimulation. Future trials should compare the effects of constant-current DBS with those of voltage-controlled stimulation. 01 February 2012
Deep brain stimulation in early stage Parkinson's disease: operative experience from a prospective randomised clinical trialThe perioperative adverse events in this trial of subjects with early stage PD are comparable with those reported for STN-DBS in advanced PD. The active contact position used in early PD is not significantly different from that used in late stage disease. 01 February 2012
Changes in cognitive-emotional and physiological symptoms of depression following STN-DBS for the treatment of Parkinson'sPreliminary results suggest that the motor improvement often observed in patients with PD following bilateral STN-DBS may be partially offset by an increase in affective-cognitive symptoms of depression. 01 January 2012
Upcoming treatments in Parkinson's disease, including gene therapyOther gene therapies, in various stages of human clinical trials, include gene transfer for the production of trophic factors, for aromatic amino acid decarboxylase alone, and most recently, a lentiviral vector transfer of an enzymatic dopamine factory consisting of three essential enzymes required for production for this neurotransmitter. 01 January 2012
Unilateral subthalamic nucleus deep brain stimulation improves sleep quality in Parkinson's diseaseThis prospective case series study provides evidence that unilateral STN DBS improves subjective sleep quality in patients with PD at up to 6 months post-operatively as measured by the PSQI. 01 January 2012
Parkinson's Disease Therapeutics: New Developments and Challenges Since the Introduction of LevodopaIt appears that the combination of early PD nonmotor symptoms with imaging of the nigrostriatal dopaminergic system offers a promising path toward the identification of PD biomarkers, which, once characterized, will set the stage for efficient use of neuroprotective agents that could slow down and alter the course of the disease 01 January 2012
Pilot Study Assessing the Feasibility of Applying Bilateral Deep Brain Stimulation in Very Early Stages of Parkinson's diseaseThis study demonstrates that it is possible to recruit and retain subjects in a clinical trial testing deep brain stimulation in early Parkinson's disease. The results of this trial will be used to support the design of a Phase III, multicenter trial investigating the efficacy of deep brain stimulation in early Parkinson's disease. 01 January 2012
Effect of Deep Brain Stimulation on Parkinson's Nonmotor Symptoms following Unilateral DBS: A Pilot StudyConclusion. Non-motor symptoms improved on two separate questionnaires following unilateral DBS for PD. Future studies are needed to confirm these findings and determine their clinical significance as well as to examine the strengths/weaknesses of each questionnaire/scale. 28 December 2011

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