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Surgery research papers

  • Neuron Striatal Molecular Signature of Subchronic Subthalamic Nucleus High Frequency Stimulation in Parkinsonian RatThis study addresses the molecular mechanisms underlying the action of subthalamic nucleus high frequency stimulation (STN-HFS) in the treatment of Parkinson's disease and its interaction with levodopa (L-DOPA), focusing on the striatum. Striatal gene expression profile was assessed in rats with nigral dopamine neuron lesion, either treated or not, using agilent microarrays and qPCR verification. 04 April 2013
  • CNS Drugs Vol 24 Iss 2 Management of Motor and Non-Motor Symptoms in Parkinson's DiseaseThis review focuses on medical and invasive treatment strategies for early and advanced stages of PD as well as on the treatment of PD non-motor symptoms such as mood and behavioural disorders, cognitive and autonomic dysfunction, and sleep disorders, which can antedate PD motor symptoms for years. 01 April 2013
  • Brain activity 80 Hz versus 130 Hz subthalamic nucleus deep brain stimulation: Effects on involuntary movementsIn this limited cohort of STN-DBS patients, we observed an improvement of residual IM after the switch of stimulation frequency from 130 Hz to 80 Hz. However, a moderate worsening of parkinsonian symptoms was observed in a portion of patients, requiring to return at 130 Hz STN-DBS. 01 April 2013
  • Neuron Developing dopaminergic cell therapy for Parkinson's diseasegive up or move forward?Factors influencing the outcome after transplantation have now been identified, and dopaminergic neurons can be generated in large numbers from stem cells. Mechanisms of graft-induced dyskinesias are much better understood, and patients with well functioning grafts can exhibit long-term motor recovery of therapeutic value even in the presence of non-motor symptoms. 15 March 2013
  • Neuron Deriving dopaminergic neurons for clinical use. A practical approachNew small molecules that regulate the step-wise differentiation of human pluripotent stem cells into dopaminergic neurons have been identified. The steroid, guggulsterone, was found to be the most effective inducer of neural stem cells into dopaminergic neurons. These neurons are extensively characterized and shown to be functional. 15 March 2013
  • Hypodermic needle and pills Impact of discontinuing tremor suppressing medications following thalamic deep brain stimulationBilateral deep brain stimulation effectively eliminated the need for tremor suppressing medications, while unilateral stimulation was not as effective in reducing medication usage. Clinicians and patients should be aware that discontinuation of primidone after surgery may worsen tremor in unilateral deep brain stimulation cases, but discontinuation will not likely impact quality of life. 01 February 2013
  • JAMA Neurology Volume 70 Issue 2 History, Applications, and Mechanisms of Deep Brain StimulationThe objective of this study is to provide a comprehensive review of DBS focusing on movement disorders, including the historical evolution of the technique, applications and outcomes with an overview of the most pertinent literature, current views on mechanisms of stimulation, and description of hardware and programming techniques. 01 February 2013
  • DNA Trophic Factor Gene Therapy for Parkinson's DiseaseRecent advances in PD research have demonstrated that gene delivery of trophic factors, glial cell linederived neurotrophic factor (GDNF) and neurturin, in particular, can provide structural and functional recovery in rodent and nonhuman primate models of PD. 31 January 2013
  • Cells neuron structure Cell Therapy for Parkinson's Disease: What Next?Based on recent promising advancements, efforts are now being made to develop standardized and efficient protocols, and adapt these protocols to good laboratory practice (GLP)/good manufacturing practice (GMP) conditions, to move this technology closer to clinical translation. 31 January 2013
  • Brain skeleton activity Stimulation of the subthalamic nucleus at an earlier disease stage of Parkinson's disease: Concept and standards of the EARLYSTIThe methodological innovation for DBS-studies of this study lies in novel procedures developed and used for monitoring best medical treatment, neurosurgical consistency, best management of stimulation programming, blinded video assessment of motor disability, and prevention of suicidal behaviors. 30 January 2013
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