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Surgery research papers
Patients' expectations of deep brain stimulation, and subjective perceived outcome related to clinical measures in Parkinson's
he mixed-method approach proved useful in examining a patient's subjective perception of STN-DBS outcome. Study results show that significant motor improvement does not necessarily lead to a positive subjective outcome. Moreover, PD patients should be screened carefully before surgery regarding apathy and depression.
01 November 2013
The cost-effectiveness of DBS in combination with best medical therapy, versus best medical therapy alone, in advanced Parkinson
The cost-effectiveness of DBS combined with BMT, versus BMT alone, was evaluated from a UK payer perspective. Individual patient-level data on the effect of DBS on PD symptom progression from a large 6-month RCT were used to develop a Markov model representing clinical progression and capture treatment effect and costs.
25 October 2013
Future of brain stimulation: New targets, new indications, new technology
The future of brain stimulation is certainly promising, especially for movement disordersthat will remain the main indication for DBS for the foreseeable futureand probably for some psychiatric disorders. However, brain stimulation as a technique may be at risk of gliding down a slippery slope: Some reports indicate a disturbing trend with suggestions that future DBS may be proposed for enhancement of memory in healthy people, or as a tool for treatment of antisocial behavior and for improving morali
07 October 2013
Parkinson disease and use of stem cells for therapeutic approaches of Parkinson disease
Embryonic stem cells, Neural stem cells, Mesenchymal stem cell and induce pluripotent stem cell are a good source for dopaminergic neurons and can be used for cellular therapeutic approaches.
02 October 2013
Neurotrophic factor expression in expandable cell populations from brain samples in living patients with Parkinson's disease
These findings confirm the feasibility of small brain biopsies as an expandable source of autologous cell substrate in living patients and demonstrate the complex phenotype of these cells, with implications for therapeutic application in PD and other neurological diseases.
01 October 2013
Long-term outcome of young onset Parkinson's disease after subthalamic stimulationA cross-sectional study
Conclusions: STN-DBS remains effective to improve motor disabilities over 7 years for YOPD and is a safe procedure concerning cognitive outcome and morbidity. However, stimulation dyskinesia and dopamine dysregulation syndrome deserve attention for the causal relationship between DBS surgery and behavioral outcomes.
01 October 2013
Amniotic Fluid Stem Cells with Low γ-Interferon Response Showed Behavioral Improvement in Parkinsonism Rat Model
In this study, AFSCs established from amniocentesis were characterized on the basis of surface marker expression and differentiation potential. To further investigate the properties of AFSCs for translational applications, authors examined the cell surface expression of human leukocyte antigens (HLA) of these cells and estimated the therapeutic effect of AFSCs in parkinsonian rats.
30 September 2013
Biomedical and Clinical Promises of Human Pluripotent Stem Cells for Neurological Disorders
In this review, authors summarize the recent reports that show how to generate neural derivatives from hPSCs, and discuss the current evidence of using these cells in animal studies. They also highlight the possibilities and concerns of translating these hPSC-derived neurons for biomedical and clinical uses in order to fight against neurological disorders.
22 September 2013
Genotype and phenotype in Parkinson's disease: Lessons in heterogeneity from deep brain stimulation
Although patients with PD who undergo deep brain stimulation (DBS) are a skewed population, they represent a valuable resource for exploring the relationships between heterogeneous phenotypes and PD genetics. In this series, 94 patients who underwent DBS were screened for mutations in the most common genes associated with PD.
15 September 2013
Deep brain stimulation for gait and postural symptoms in Parkinson's disease
In this review, authors summarize the effects of deep brain stimulation on gait and postural symptoms in the five currently available targets (subthalamic nucleus, globus pallidus, ventralis intermedius thalamic nucleus, pedunculopontine nucleus, and substantia nigra) and describe programming strategies for patients who are mainly disabled by gait problems.
15 September 2013
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