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Surgery research papers
Subthalamic stimulation modulates cortical motor network activity and synchronization in Parkinson's disease
This study demonstrates wide-spread activity and synchronization modulations of the cortical motor network, and highlights subthalamic stimulation as a network-modulating therapy. Accordingly, subthalamic stimulation may release bilateral cortical computational resources by facilitating movement-related desynchronization. Moreover, the subthalamic nucleus is critical to balance inhibitory and facilitatory cortical players within the motor program.
01 March 2015
Neuropsychological outcome after deep brain stimulation for Parkinson disease
Conclusions: Authors found no clinically significant differences in neuropsychological outcome between GPi DBS and STN DBS. No satisfactory explanation is available for the predictive value of baseline semantic fluency for cognitive decline.
27 February 2015
Cellular mechanisms of deep brain stimulation: activity-dependent focal circuit reprogramming?
Authors eview progress made during the last decade focusing in particular on how recent methods for targeted circuit manipulations, imaging and reconstruction are fostering preclinical and translational advances that improve our neurobiological understanding of DBS's action in psychiatric disorders.
20 February 2015
Parkinson's Disease, the Subthalamic Nucleus, Inhibition, and Impulsivity
Though the results are not always consistent, nevertheless, this body of evidence supports the role of the STN in inhibitory and executive control.
15 February 2015
Effect of Neurostimulation on Camptocormia in Parkinson's Disease Depends on Symptom Duration
data indicate that the main prognostic factor for a beneficial DBS effect on camptocormia is its short duration. As an explanation, we suggest that neurostimulation may improve camptocormia only as long as muscle pathology is limited. Our findings may help to elucidate the mode of action of neurostimulation.
12 February 2015
Motion Sensor Strategies for Automated Optimization of Deep Brain Stimulation in Parkinson's disease
Conclusions: Objective assessment in DBS programming can identify settings that improve symptoms or obtain similar benefit as clinicians with improvement in battery life. Both options have the potential to improve post-operative patient outcomes.
10 February 2015
Short pulse width widens the therapeutic window of subthalamic neurostimulation
Measured chronaxies and model data suggest, that pulse durations <60 μsec lead to a focusing of the neurostimulation effect on smaller diameter axons close to the electrode while avoiding stimulation of distant pyramidal tract fibers.
31 January 2015
Preoperative brain metabolism and quality of life after subthalamic nucleus stimulation in Parkinson's disease
STN-DBS may have interfered with this already abnormal circuitry, leading to the occurrence of complex nonmotor symptoms reducing quality of life. Preoperative brain metabolism could be a useful biomarker for anticipating STN-DBS efficacy in terms of HRQoL in the context of advanced PD.
30 January 2015
Low-frequency stimulation of STN-DBS reduces aspiration and freezing of gait in patients with PD
Conclusions: Compared with the routine 130 Hz, the 60-Hz stimulation significantly improved swallowing function, FOG, and axial and parkinsonian symptoms in patients with PD treated with bilateral STN-DBS, which persisted over the 6-week study period.
27 January 2015
Weight gain following subthalamic nucleus deep brain stimulation: A PET study
Authors analyzed the correlation between changes in brain metabolism (using positron emission tomography [PET] imaging) and weight gain after bilateral subthalamic nucleus DBS in patients with Parkinson's disease. Body mass index was calculated and brain activity prospectively measured using 2-deoxy-2[18F]fluoro-d-glucose 3 months before and 4 months after the start of subthalamic nucleus deep brain stimulation in 23 patients with Parkinson's disease.
15 December 2014
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