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Surgery research papers
Mitomycin-treated undifferentiated embryonic stem cells as a safe & effective therapeutic strategy in mouse model of Parkinson's
Study findings indicate that treating mESCs with MMC prior to intrastriatal transplant is an effective to strategy that could be further investigated as a novel alternative for treatment of PD.
08 April 2015
Translational research for Parkinsons disease: The value of pre-clinical primate models
In this review authors focus on Parkinsons and on the impact of a body of data issued from NHP studies. They attempt to critically examine the advantages and limitations of various approaches from the perspective of the animal model used to address specific questions.
02 April 2015
Mitochondrial Alterations by PARKIN in Dopaminergic Neurons Using PARK2 Patient-Specific and PARK2 Knockout Isogenic iPSC Lines
Study results are consistent with current model of PARK2 function where damaged mitochondria are targeted for degradation via a PARK2/PINK1-mediated mechanism.
02 April 2015
Motion Sensor Strategies for Automated Optimization of Deep Brain Stimulation in Parkinson's disease
Conclusions: Objective assessment in DBS programming can identify settings that improve symptoms or obtain similar benefit as clinicians with improvement in battery life. Both options have the potential to improve post-operative patient outcomes.
01 April 2015
Neuropsychological outcome after deep brain stimulation for Parkinson disease
Conclusions: Authors found no clinically significant differences in neuropsychological outcome between GPi DBS and STN DBS. No satisfactory explanation is available for the predictive value of baseline semantic fluency for cognitive decline.
31 March 2015
Varying time-course of effects of high frequency stimulation of sub-regions of the Globus pallidus in patients with Parkinson's
Conclusions: Benefits on the off-medication symptoms of PD obtained acutely with GPe-DBS are in general not sustained. Similarly, the effects of GPi-DBS on the off medication symptoms of PD, can evolve over short periods of time presumably as a result of changes in network-wide neuronal plasticity. These clinical observations provide further insight into DBS mechanism of action, and can also help inform optimal methods of GPi-DBS programming.
26 March 2015
An 8-Year Follow-up on the Effect of Subthalamic Nucleus Deep Brain Stimulation on Pain in Parkinson Disease
Conclusions and Relevance: Pain associated with PD is improved by STN DBS, and the beneficial effect persists after a long-term follow-up of 8 years. In addition, new pain, especially the musculoskeletal type, developed in most patients, becoming a long-term distressing problem.
23 March 2015
The medical treatment of patients with Parkinson's disease receiving subthalamic neurostimulation
Conclusion: STN-DBS allows for a reduction in the dosage of medication and the costs are similarly reduced. In this cohort different medication groups were reduced to a similar extent. Patients' demographic factors did not play a major role in the selection of treatment.
22 March 2015
Successful Function of Autologous iPSC-Derived Dopamine Neurons following Transplantation in Primate Model of Parkinson's
In one animal, with the most successful protocol, authors found that unilateral engraftment of CM-iPSCs could provide a gradual onset of functional motor improvement contralateral to the side of dopamine neuron transplantation, and increased motor activity, without a need for immunosuppression.
05 March 2015
Subthalamic stimulation modulates cortical motor network activity and synchronization in Parkinson's disease
This study demonstrates wide-spread activity and synchronization modulations of the cortical motor network, and highlights subthalamic stimulation as a network-modulating therapy. Accordingly, subthalamic stimulation may release bilateral cortical computational resources by facilitating movement-related desynchronization. Moreover, the subthalamic nucleus is critical to balance inhibitory and facilitatory cortical players within the motor program.
01 March 2015
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