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Surgery research papers

Initial cognitive dip after subthalamic deep brain stimulation in Parkinson diseaseThis study examined whether the rate of change in global cognitive function during the initial 6 months after STN DBS was different from the mean 6-month change that occurred between 6 and 36 months after surgery. 17 May 2013
Urinary profile of catecholamines and metabolites in Parkinson patients with deep brain stimulationConclusion: After DBS-STN, the DA/l-DOPA ratio, an indirect measure of DA synthesis, increased. These results show that DBS-STN may improve the efficacy of oral levodopa. 16 May 2013
Human Embryonic Stem Cells Derived by Somatic Cell Nuclear TransferPast attempts to produce human NT-ESCs have failed secondary to early embryonic arrest of SCNT embryos. Here, authors identified premature exit from meiosis in human oocytes and suboptimal activation as key factors that are responsible for these outcomes. 15 May 2013
Subthalamic Nucleus Neurons Are Synchronized to Primary Motor Cortex Local Field Potentials in Parkinson'sHere, in humans undergoing deep brain stimulator implantation surgery, authors use the novel technique of subdural electrocorticography in combination with subthalamic nucleus (STN) single-unit recording to study basal gangliacortex interactions at the millisecond time scale. 24 April 2013
Progress in gene therapy for neurological disordersIn this Review, authors describe the promising gene therapy strategies that have the potential to treat patients with neurological diseases and discuss prospects for future development of gene therapy. 23 April 2013
Parkinson disease: Neurostimulation in PDbenefit of early surgery revealedWith disease progression, however, the response to dopamine replacement therapy becomes less consistent and less predictable, and drug-induced dyskinesias are experienced by the majority of patients. 16 April 2013
Cost-effectiveness of deep brain stimulation in patients with Parkinson's diseaseAuthors performed a cost-utility analysis using a lifetime Markov model for Parkinson's disease. Health utilities were evaluated using the EQ-5D generic health status measure. Data on effectiveness and adverse events were obtained from clinical studies, published reports, or meta-analyses. 10 April 2013
Power failure: why small sample size undermines the reliability of neuroscienceA study with low statistical power has a reduced chance of detecting a true effect, but it is less well appreciated that low power also reduces the likelihood that a statistically significant result reflects a true effect. Here, authors show that the average statistical power of studies in the neurosciences is very low. 10 April 2013
Parkinson's disease redefinedParkinson's disease can be regarded as a generational illness, not only because of its incidence in elderly people, but also because of the changing conceptualisation of the disorder across generations of doctors and researchers. Disease conceptualisation has changed along three epochs since the initial description of the shaking palsy by James Parkinson, and after Charcot's elaboration on the clinical phenotype. 09 April 2013
Striatal Molecular Signature of Subchronic Subthalamic Nucleus High Frequency Stimulation in Parkinsonian RatThis study addresses the molecular mechanisms underlying the action of subthalamic nucleus high frequency stimulation (STN-HFS) in the treatment of Parkinson's disease and its interaction with levodopa (L-DOPA), focusing on the striatum. Striatal gene expression profile was assessed in rats with nigral dopamine neuron lesion, either treated or not, using agilent microarrays and qPCR verification. 04 April 2013

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