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Surgery research papers
Which target is best for patients with Parkinson's disease? A meta-analysis of pallidal and subthalamic stimulation
The effect of GPi DBS was similar to STN DBS except for depression, however, only three studies described depression as adverse events. We need additional randomised trials with direct comparison between targets based on unified scoring of adverse events.
01 September 2014
Effects of deep brain stimulation of the subthalamic nucleus on freezing of gait in Parkinson's: a prospective controlled study
In contrast to continued BMT, STN-DBS reduced FOG occurrence and severity at 6 months postsurgery with largely sustained effects at 12 months follow-up. Longer follow-up periods are needed to test whether FOG improvements after STN-DBS persist with disease progression.
01 August 2014
Stimulation of the pedunculopontine nucleus area in Parkinson's disease: effects on speech and intelligibility
Although limited in this group of patients, speech impairment following pedunculopontine nucleus area stimulation is a possible outcome that should be considered before undertaking such surgery. Deleterious effects could be dependent on electrode insertion in this brainstem structure, more than on current spread to nearby structures involved in speech control.
30 July 2014
Network modulation following sham surgery in Parkinson's disease
Patient responses to placebo and sham effects are a major obstacle to the development of therapies for brain disorders, including Parkinson's disease (PD). Here, we used functional brain imaging and network analysis to study the circuitry underlying placebo effects in PD subjects randomized to sham surgery as part of a double-blind gene therapy trial.
18 July 2014
Impulse control behaviours in patients with Parkinson's after subthalamic DBS: de novo cases and 3-year follow-up
Conclusions ICBs were abolished in patients 3 years after STN DBS and DAA dosages were lowered. New ICBs may occur after implant and are transient in most cases. Compulsive eating may be specifically related to STN stimulation.
10 July 2014
Subthalamic nucleus deep brain stimulation in early stage Parkinson's disease
This study demonstrates that subjects with early stage PD will enroll in and complete trials testing invasive therapies and provides preliminary evidence that DBS is well tolerated in early PD. The results of this trial provide the data necessary to design a large, phase III, double-blind, multicenter trial investigating the safety and efficacy of DBS in early PD.
01 July 2014
The Impact of STN Deep Brain Stimulation on Speech in Individuals with Parkinson's Disease: The Patient's Perspective
Conclusion: DBS therapy's contribution to speech disturbance is gaining more attention, and the speech symptoms ensuing from and/or being exacerbated by DBS are in the incipient stages of being investigated. Implications for DBS therapy on perceived quality of life are discussed.
30 June 2014
Coordinated reset neuromodulation for Parkinson's disease: Proof-of-concept study
Results: Coordinated reset neuromodulation of the subthalamic nucleus (STN) applied to six PD patients in an externalized setting during three stimulation days induced a significant and cumulative reduction of beta band activity that correlated with a significant improvement of motor function.
28 June 2014
Long-Term Health of Dopaminergic Neuron Transplants in Parkinson's Disease Patients
To determine the long-term health and function of transplanted dopamine neurons in Parkinson's disease (PD) patients, the expression of dopamine transporters (DATs) and mitochondrial morphology were examined in human fetal midbrain cellular transplants.
26 June 2014
Subthalamic deep brain stimulation: clinical and neuropsychological outcomes in mild cognitive impaired parkinsonian patients
Study findings confirm the sustained long-lasting efficacy of STN-DBS on motor functions in both PD-MCI and normal cognition subjects. PD-MCI patients showed a more precocious cognitive impairment, as expected by natural history studies, but no case of dementia was observed early after surgery.
22 June 2014
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