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Surgery research papers
Myths and Facts About the EARLYSTIM Study
The EARLYSTIM study has shown that STN-DBS may be proposed earlier on in the course of PD, as soon as motor complications start to cause relevant disability despite proper medical management. This can lead to a gain of several years of improved QoL.
14 November 2014
The impact of subthalamic deep brain stimulation on caregivers of Parkinson's disease patients: an exploratory study
Study results show that at 1-year FU over 50 % of the caregivers rated their subjective well-being as negative. Especially older and more depressed caregivers are at risk. These caregivers and their partners should be monitored more closely to identify possible problems and help them adapt following surgery.
09 November 2014
Weight gain following subthalamic nucleus deep brain stimulation: A PET study
Authors analyzed the correlation between changes in brain metabolism (using positron emission tomography [PET] imaging) and weight gain after bilateral subthalamic nucleus DBS in patients with Parkinson's disease. Body mass index was calculated and brain activity prospectively measured using 2-deoxy-2[18F]fluoro-d-glucose 3 months before and 4 months after the start of subthalamic nucleus deep brain stimulation in 23 patients with Parkinson's disease.
07 November 2014
Human ESC-Derived Dopamine Neurons Show Similar Preclinical Efficacy & Potency to Fetal Neurons when Grafted in Rat Model of PD
Authors show long-term survival and functionality using clinically relevant MRI and PET imaging techniques and demonstrate efficacy in restoration of motor function with a potency comparable to that seen with human fetal dopamine neurons. Furthermore, they show that hESC-derived dopamine neurons can project sufficiently long distances for use in humans, fully regenerate midbrain-to-forebrain projections, and innervate correct target structures.
06 November 2014
The Future of Research in Parkinson Disease
There are many unanswered questions about Parkinson disease (PD), but as a result of advances in genetics, proteomics, metabolomics, epigenetics, imaging, and other novel techniques, remarkable progress is being made. In this Viewpoint, authors will highlight aspects of future research aimed at addressing the following critical questions.
01 November 2014
Predicting quality of life outcomes after subthalamic nucleus deep brain
The findings provide greater insight into the nonmotor features that contribute to the success of subthalamic nucleus DBS procedures from the patient's perspective and raise questions about the treatment focus and emphasis on symptom profiles in DBS candidacy evaluations.
28 October 2014
Autonomic symptoms in Parkinson's disease
Despite a growing interest in the problem of autonomic dysfunction in PD, few studies have focused on autonomic dysfunction in PD, the patient's perspective about autonomic symptoms, and the relative differences between DBS and Non-DBS participants with respect to autonomic disturbances.
23 October 2014
Changes in Vowel Articulation with Subthalamic Nucleus Deep Brain Stimulation in Dysarthric Speakers with Parkinson's Disease
Results suggest that STN DBS may improve articulation in dysarthric speakers with PD, in terms of range of movement. Optimization of the electrical parameters for each patient is important and may lead to improvement in speech fine motor control. However, the impact on overall speech intelligibility may still be small.
21 October 2014
Outcomes, Management, and Potential Mechanisms of Interleaving Deep Brain Stimulation Settings
Conclusions: Interleaving is a tool that may augment outcomes, and possibly obviate the need for surgical revisions, although in our experience across two large centers it has been effective for only a small number of patients.
20 October 2014
Parkinson's Disease, the Subthalamic Nucleus, Inhibition, and Impulsivity
Though the results are not always consistent, nevertheless, this body of evidence supports the role of the STN in inhibitory and executive control.
09 October 2014
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