15 November 2011
Nishida N, Murakami T, Kadoh K, Tohge R,
Yamanegi M, Saiki H, Ueda K, Matsumoto S, Ishikawa M, Takahashi JA, Toda H
Background: In Parkinson's disease, sleep disturbance is a common occurrence.
Methods: We
evaluated sleep in 10 patients with Parkinson's disease (age, 57.5 ±
9.8 years; disease duration, 12.3 ± 2.7 years) before and after
subthalamic nucleus deep brain stimulation using the Parkinson's disease
sleep scale and polysomnography.
Results: Their
total sleep scale scores and daytime sleepiness subscale scores
significantly improved after subthalamic nucleus-deep brain stimulation.
The novel findings from this study significantly increased normal rapid
eye movement sleep, and decreased abnormal rapid eye movement sleep
without atonia after deep brain stimulation in patients with Parkinson's
disease. The improved total sleep scale score correlated with decreased
wakefulness after sleep onset. Moreover, improved daytime sleepiness
correlated with increased normal rapid eye movement sleep time. Sleep
improvement did not significantly correlate with resolution of motor
complication or reduced dopaminergic dosages.
Conclusions: Subthalamic
nucleus-deep brain stimulation may have beneficial effects on sleep
disturbance in advanced Parkinson's disease by restoring sleep
architecture and normal rapid eye movement sleep.
