January 2012
Lee
JY, Jeon BS, Kim HJ, Park SS
Objectives To determine the role of a serotonin 2A receptor gene (=HTR2A) variant in the development of impulse control and repetitive behaviors in Parkinson’s disease.
Methods We
performed a genetic association analysis to a cohort of 404 Korean
patients with Parkinson’s disease who had been enrolled in a previous
study. Presence of impulse control and repetitive behaviors was screened
using modified version of Minnesota Impulsive Disorders Interview and
genotyping for HTR2A c.102T > C was performed using the TaqMan assay.
Results The
T allele, which is presumably linked to higher receptor expression, was
marginally associated with impulse control and repetitive behaviors in
Parkinson’s disease; the genetic influence was significantly enhanced in
the lower levodopa-equivalent-dose group, increasing the risk by 2.8
and 6.9 times in CT and TT carriers, respectively (p-trend = 0.011).
There was no significant interaction between the c.102T > C variant
and clinical risk variables such as sex, age at onset, total daily
levodopa-equivalent-dose, use of dopamine agonist and daily dose of
dopamine agonist.
Conclusion Our data support a possible contribution of genetic variation in the HTR2A to the susceptibility to impulse control and repetitive behaviors in Parkinson’s disease.
