Research papers

Search for

ALL research papers

Deep brain stimulation in early stage Parkinson's disease: operative experience from a prospective randomised clinical trialThe perioperative adverse events in this trial of subjects with early stage PD are comparable with those reported for STN-DBS in advanced PD. The active contact position used in early PD is not significantly different from that used in late stage disease. 01 February 2012
Grey matter atrophy in cognitively impaired Parkinson's diseaseMarked grey matter atrophy occurs in PD with dementia but far less extensive changes are evident in PD-MCI. Some grey matter atrophy precedes the development of dementia but may be accelerated once frank dementia begins. 01 February 2012
Subthalamic deep brain stimulation with a constant-current device in Parkinson's disease: an open-label randomised controlled trInterpretation: Constant-current DBS of the subthalamic nucleus produced significant improvements in good quality on time when compared with a control group without stimulation. Future trials should compare the effects of constant-current DBS with those of voltage-controlled stimulation. 01 February 2012
Complaints about impairments in executive functions in Parkinson's disease: The association with neuropsychological assessmentPD patients were aware of problems with executive functions in daily life and reported considerably more problems than healthy controls. These problems were however not reflected by neuropsychological tests and may indicate a lack of ecological validity of neuropsychological assessment. 01 February 2012
Appreciation of humor is decreased among patients with Parkinson's diseaseConclusions: Patients with PD have a decreased sense of humor compared to healthy controls. Utilizing audio methods of presentation and humor in an obvious mode appears to be the preferred approach for eliciting responses to humor in a PD population. 01 February 2012
RGS4 Is Required for Dopaminergic Control of Striatal LTD and Susceptibility to Parkinsonian Motor DeficitsThis study identified regulator of G protein signaling 4 (RGS4) as a key link between D2/A2A signaling and eCB mobilization pathways. In contrast to wild-type mice, RGS4/ mice exhibited normal eCB-LTD after dopamine depletion and were significantly less impaired in the 6-OHDA model of Parkinson's disease. Taken together, these results suggest that inhibition of RGS4 may be an effective nondopaminergic strategy for treating Parkinson's disease. 26 January 2012
Nonmotor manifestations of Parkinson's diseaseIn addition, a number of nonmotor manifestations can precede the onset of motor symptoms in PD and can be used as screening tools allowing for early disease identification and for trials of possible disease-modifying interventions. This article reviews depression, sleep, and autonomic dysfunction in PD. 25 January 2012
Polyneuropathy while on duodenal levodopa infusion in Parkinson's disease patients: we must be alertVitamin B12 supplementation may need to be considered in PD patients on duodenal levodopa infusion therapy. Vitamin B12 deficiency in patients on duodenal levodopa infusion therapy may be more frequent than the published data suggest. We must be alert. 24 January 2012
Movement orientation switching with the eyes and lower limb in Parkinson diseaseIn PD, switch time and movement velocity of the lower limb, but not the eyes, correlated with bradykinesia and postural instability/gait. Study results suggest that individuals with PD experience movement-switching deficits with both the eyes and lower limb, perhaps driven by overall bradykinesia. 18 January 2012
A randomized, double-blind, placebo-controlled trial of safinamide as add-on therapy in early Parkinson's disease patientsExploratory analysis of the primary endpoint for 100 mg/day demonstrated that the addition of safinamide to a stable dose of DA improves motor symptoms in early PD and warrants further investigation. 15 January 2012

Page: [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [+11]

[ Next » ]