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RGS4 Is Required for Dopaminergic Control of Striatal LTD and Susceptibility to Parkinsonian Motor DeficitsThis study identified regulator of G protein signaling 4 (RGS4) as a key link between D2/A2A signaling and eCB mobilization pathways. In contrast to wild-type mice, RGS4/ mice exhibited normal eCB-LTD after dopamine depletion and were significantly less impaired in the 6-OHDA model of Parkinson's disease. Taken together, these results suggest that inhibition of RGS4 may be an effective nondopaminergic strategy for treating Parkinson's disease. 26 January 2012
Role of serotonergic 1A receptor dysfunction in depression associated with Parkinson's diseaseThe present imaging study suggests that abnormalities in serotonin 1A receptor neurotransmission in the limbic system may be involved in the neural mechanisms underlying depression in patients with Parkinson's disease. 15 January 2012
Norepinephrine: the next therapeutics frontier for Parkinson's diseaseDespite the major roles of NE throughout the brain, there has been only minimal exploration of pharmacological intervention with NErgic neurotransmission.... This article reviews the reported pharmacological experience in PD therapeutics. 13 January 2012
A DNA resequencing array for genes involved in Parkinson's diseaseThe authors propose that this technology offers a robust and cost-effective alternative to targeted sequencing using traditional sequencing methods, and here we demonstrate the potential of this approach for either routine clinical investigation or for research studies aimed at understanding the genetic aetiology of PD. 12 January 2012
Genetic bases and phenotypes of autosomal recessive Parkinson disease in a Turkish populationStudy data suggest that the PRKN gene mutation is the most frequent form of ARPD in Turkey. The proportion of mutations with regard to the age of onset in our population is in the range of those previously described, but our pedigrees are characterized by high rate of consanguinity, which might explain the high proportion of families with homozygous mutations and of patients in more than one generation. 10 January 2012
Evidence of an association between the scavenger receptor class B member 2 gene and Parkinson's diseaseThis study supports a genetic contribution of the SCARB2 locus to PD; future studies in larger cohorts are necessary to verify this finding. 05 January 2012
parkin-induced defects in neurophysiology and locomotion are generated by metabolic dysfunction and not oxidative stressThe authors therefore propose that mitochondrial dysfunction in parkin mutants induces Parkinsonian bradykinesia via a neuronal energy deficit and resulting synaptic failure, rather than as a consequence of downstream oxidative stress. 03 January 2012
Mutations in the parkin gene are a minor cause of Parkinson's disease in the South African populationIn conclusion, the present study reveals that mutations in the parkin gene are not a major contributor to PD in the South African population. Further investigations of the molecular etiology of PD in the unique South African population, particularly the Black African and mixed ancestry sub-populations, are warranted. 01 January 2012
Upcoming treatments in Parkinson's disease, including gene therapyOther gene therapies, in various stages of human clinical trials, include gene transfer for the production of trophic factors, for aromatic amino acid decarboxylase alone, and most recently, a lentiviral vector transfer of an enzymatic dopamine factory consisting of three essential enzymes required for production for this neurotransmitter. 01 January 2012
An approach to finding brain-situated mutations in sporadic Parkinson's diseaseThis study shows that PD brain CNVs can be detected, and raises the possibility that brain-situated mutations could underlie some cases of PD. A method of undertaking a definitive study of brain somatic mutations in PD, using massively parallel sequencing and multiple tissues, is suggested. 01 January 2012

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