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Surgery research papers

Deep brain stimulation in early stage Parkinson's disease: operative experience from a prospective randomised clinical trialThe perioperative adverse events in this trial of subjects with early stage PD are comparable with those reported for STN-DBS in advanced PD. The active contact position used in early PD is not significantly different from that used in late stage disease. 01 February 2012
Subthalamic deep brain stimulation with a constant-current device in Parkinson's disease: an open-label randomised controlled trInterpretation: Constant-current DBS of the subthalamic nucleus produced significant improvements in good quality on time when compared with a control group without stimulation. Future trials should compare the effects of constant-current DBS with those of voltage-controlled stimulation. 01 February 2012
Parkinson's Disease Therapeutics: New Developments and Challenges Since the Introduction of LevodopaIt appears that the combination of early PD nonmotor symptoms with imaging of the nigrostriatal dopaminergic system offers a promising path toward the identification of PD biomarkers, which, once characterized, will set the stage for efficient use of neuroprotective agents that could slow down and alter the course of the disease 01 January 2012
Unilateral subthalamic nucleus deep brain stimulation improves sleep quality in Parkinson's diseaseThis prospective case series study provides evidence that unilateral STN DBS improves subjective sleep quality in patients with PD at up to 6 months post-operatively as measured by the PSQI. 01 January 2012
Changes in cognitive-emotional and physiological symptoms of depression following STN-DBS for the treatment of Parkinson'sPreliminary results suggest that the motor improvement often observed in patients with PD following bilateral STN-DBS may be partially offset by an increase in affective-cognitive symptoms of depression. 01 January 2012
Upcoming treatments in Parkinson's disease, including gene therapyOther gene therapies, in various stages of human clinical trials, include gene transfer for the production of trophic factors, for aromatic amino acid decarboxylase alone, and most recently, a lentiviral vector transfer of an enzymatic dopamine factory consisting of three essential enzymes required for production for this neurotransmitter. 01 January 2012
Subthalamic neuronal responses to cortical stimulationConclusions: To prevent seizures the current density should be lowered, so that motor cortex stimulation-evoked responses can be safely used during deep brain stimulation surgery. 30 December 2011
Effect of Deep Brain Stimulation on Parkinson's Nonmotor Symptoms following Unilateral DBS: A Pilot StudyConclusion. Non-motor symptoms improved on two separate questionnaires following unilateral DBS for PD. Future studies are needed to confirm these findings and determine their clinical significance as well as to examine the strengths/weaknesses of each questionnaire/scale. 28 December 2011
Critical Aspects of Clinical Trial Design for Novel Cell and Gene TherapiesDetailed evaluation of these discordant findings has highlighted several crucial issues such as patient selection criteria, details surrounding transplantation or gene therapy methodologies, as well as the study designs themselves that ought to be carefully considered in the planning phases of future clinical trials. 28 December 2011
Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's diseaseIn vivo survival and function is demonstrated in Parkinson's disease models using three host species. Long-term engraftment in 6-hydroxy-dopamine-lesioned mice and rats demonstrates robust survival of midbrain DA neurons derived from human embryonic stem (ES) cells, complete restoration of amphetamine-induced rotation behaviour and improvements in tests of forelimb use and akinesia. 21 December 2011

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