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Significant pathological heterogeneity within PD‐MCI was found. This included varying Lewy body stages, Alzheimer's disease pathology, and cerebral amyloid angiopathy. There was a significant increase in the severity of Lewy body pathology (meeting The Unified Staging System for Lewy Body disorders neocortical stage) in nonamnestic MCI (7/1, 63%) when compared with amnestic MCI (3/14, 21%, P = 0.032). Although a small study, distinct pathological changes may contribute to PD‐MCI phenotype.

Read more in Movement Disorders 2020 May. Vol. 35(5); 845-850

doi: 10.1002/mds.27991

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